Biology subjects

THEVENEAU, E.

Publications and source records attributed to THEVENEAU, E..

2 recordsLinked to original sources

bioRxiv2020

Transcriptional regulation of EMT by nuclear MMP28

Epithelial-Mesenchymal Transition (EMT) is an early event in cell dissemination from epithelial tissues. EMT endows cells with migratory, and sometimes invasive, capabilities and is thus a key process in embryo morphogenesis and cancer progression. So far, Matrix Metalloproteinases (MMPs) have not been considered as key players in EMT but rather studied for their role in matrix remodelling in later events such as cell migration per se. Here we used Xenopus neural crest cells to assess the role of MMP28 in EMT and migration in vivo. We provide strong evidence indicating that MMP28 produced by neighbouring placode cells is imported in the nucleus of neural crest cells for EMT and migration to occur.

developmental biology↗

bioRxiv2019

Dynamic expression of MMP28 during cranial morphogenesis

Matrix metalloproteinases (MMP) are a large family of proteases comprising 24 members in vertebrates. They are well known for their extracellular matrix remodelling activity. MMP28 is the last member of the family to be discovered. It is a secreted MMP involved in wound healing, immune system maturation, cell survival and migration. MMP28 is also expressed during embryogenesis in human and mouse. Here we describe the detailed expression profile of MMP28 in Xenopus laevis embryos. We show that MMP28 is expressed maternally and accumulates at neurula and tailbud stages specifically in the cranial placode territories adjacent to migrating neural crest cells. As a secreted MMP, MMP28 may be required in normal neural crest-placode interactions.

developmental biology↗