Biology subjects

Svirsky, M. A.

Publications and source records attributed to Svirsky, M. A..

4 recordsLinked to original sources

bioRxiv2024

A level adjusted cochlear frequency-to-place map for estimating tonotopic frequency mismatch with a cochlear implant

ObjectivesTo provide a level-adjusted correction to the current standard relating anatomical cochlear place to characteristic frequency in humans, and to re-evaluate anatomical frequency mismatch in cochlear implant (CI) recipients considering this correction. It is hypothesized that a level-adjusted place-frequency function may represent a more accurate tonotopic benchmark for CIs in comparison to the current standard. DesignThe present analytical study compiled data from fifteen previous animal studies that reported iso-intensity responses from cochlear structures at different stimulation levels. Extracted outcome measures were characteristic frequencies and centroid-based best frequencies at 70 dB SPL input from 47 specimens spanning a broad range of cochlear locations. A simple relationship was used to transform these measures to human estimates of characteristic and best frequencies, and non-linear regression was applied to these estimates to determine how the standard human place-frequency function should be adjusted to reflect best frequency rather than characteristic frequency. The proposed level-adjusted correction was then compared to average place-frequency positions of commonly used CI devices when programmed with clinical settings. ResultsThe present study showed that the best frequency at 70 dB SPL (BF70) tends to shift away from characteristic frequency (CF). The amount of shift was statistically significant (signed-rank test z = 5.143, p < 0.001), but the amount and direction of shift depended on cochlear location. At cochlear locations up to 600{degrees} from the base, BF70 shifted downwards in frequency relative to CF by about 4 semitones on average. Beyond 600{degrees} from the base, BF70 shifted upwards in frequency relative to CF by about 6 semitones on average. In terms of spread (90% prediction interval), the amount of shift between CF and BF70 varied from relatively no shift to nearly an octave of shift. With the new level-adjusted frequency-place function, the amount of anatomical frequency mismatch for devices programmed with standard of care settings is less extreme than originally thought, and may be nonexistent for all but the most apical electrodes. ConclusionsThe present study validates the current standard for relating cochlear place to characteristic frequency, and introduces a level-adjusted correction for how best frequency shifts away from characteristic frequency at moderately loud stimulation levels. This correction may represent a more accurate tonotopic reference for CIs. To the extent that it does, its implementation may potentially enhance perceptual accommodation and speech understanding in CI users, thereby improving CI outcomes and contributing to advancements in the programming and clinical management of CIs.

neuroscience↗

bioRxiv2022

Capabilities of the CCi-Mobile Cochlear Implant Research Platform for Real-Time Sound Coding

One important obstacle to optimizing fitting and sound coding for auditory implants is lack of flexible, powerful and portable platforms that can be used in real-world listening environments by implanted patients. The clinical processors and the typically available research tools either do not have sufficient computational power and flexibility or are not portable. In response to this need, the Center for Robust Speech Systems (CRSS) at the University of Texas at Dallas has developed CCI-Mobile, in collaboration with the Laboratory for Translational Auditory Research at New York University School of Medicine and the Binaural Hearing and Speech Laboratory at the University of Wisconsin-Madison. The CCI-Mobile platform provides unique flexibility to implement a variety of real-time sound coding algorithms in real-world environments, including algorithms that require synchronized binaural stimulation. In this paper, we will describe the overall architecture of the CCI-Mobile platform and provide practical considerations for designing real-time sound coding algorithms with this platform. CCI-Mobile is under development and future generations may provide further functionality, beyond what is described in this paper.

bioengineering↗

bioRxiv2021

Locus coeruleus activity improves cochlear implant performance

Cochlear implants are neuroprosthetic devices that can provide hearing to deaf patients1. Despite significant benefits offered by cochlear implants, there are highly variable outcomes in how quickly hearing is restored and perceptual accuracy after months or years of use2,3. Cochlear implant use is believed to require neuroplasticity within the central auditory system, and differential engagement of neuroplastic mechanisms might contribute to outcome variability4-7. Despite extensive studies on how cochlear implants activate the auditory system4,8-12, our understanding of cochlear implant-related neuroplasticity remains limited. One potent factor enabling plasticity is the neuromodulator norepinephrine from the brainstem locus coeruleus. Here we examined behavioral responses and neural activity in locus coeruleus and auditory cortex of deafened rats fitted with multi-channel cochlear implants. Animals were trained on a reward-based auditory task, with considerable individual differences of learning rates and maximum performance. Photometry from locus coeruleus predicted when implanted subjects would begin responding to sounds and longer-term perceptual accuracy, which were augmented by optogenetic locus coeruleus stimulation. Auditory cortical responses to cochlear implant stimulation reflected behavioral performance, with enhanced responses to rewarded stimuli and decreased distinction between unrewarded stimuli. Adequate engagement of central neuromodulatory systems is thus a potential clinically-relevant target for optimizing neuroprosthetic device use.

neuroscience↗

bioRxiv2020

Reducing interaural tonotopic mismatch preserves binaural unmasking in cochlear implant simulations of single-sided deafness

Binaural unmasking, a key feature of normal binaural hearing, refers to the improved intelligibility of masked speech by adding masking noise that facilities perceived spatial separation of target and masker. A question particularly relevant for cochlear implant users with single-sided deafness (SSD-CI) is whether binaural unmasking can still be achieved if the additional masking is distorted. Adding the CI restores some aspects of binaural hearing to these listeners, although binaural unmasking remains limited. Notably, these listeners may experience a mismatch between the frequency information perceived through the CI and that perceived by their normal hearing ear. Employing acoustic simulations of SSD-CI with normal hearing listeners, the present study confirms a previous simulation study that binaural unmasking is severely limited when interaural frequency mismatch between the input frequency range and simulated place of stimulation exceeds 1-2 mm. The present study also shows that binaural unmasking is largely retained when the input frequency range is adjusted to match simulated place of stimulation, even at the expense of removing low-frequency information. This result bears implication for the mechanisms driving the type of binaural unmasking of the present study, as well as for mapping the frequency range of the CI speech processor in SSD-CI users.

neuroscience↗