Biology subjects

Sun, Z. Y.

Publications and source records attributed to Sun, Z. Y..

3 recordsLinked to original sources

bioRxiv2026

FAST BOLD FMRI REVEALS THE SPATIOTEMPORAL COMPLEXITY OF NEUROVASCULAR COUPLING ALTERATIONS IN CEREBRAL SMALL VESSEL DISEASE

Recent advances in neurophysiology highlighted the potential of high temporal resolution in Blood-Oxygen Level Dependent (BOLD) functional MRI (fMRI), although it is not yet standard practice. We demonstrated that fast BOLD fMRI can detect single-subject, single-stimulus visually evoked responses to brief stimuli at 3T. We used fast fMRI in patients with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), a genetic form of cerebral small vessel disease (cSVD). Using 2- and 10-second visual stimuli, we probed different neurovascular coupling regimes and showed that different regions of interest detect different facets of vascular dynamics. CADASIL patients showed significant changes in the amplitude and timing of the BOLD response, indicating early-age neurovascular impairment unrelated to anatomical lesions, and providing strong discriminative and generalization performance. These findings resolve prior inconsistencies in fMRI studies of CADASIL, supporting the use of fast fMRI to develop non-invasive biomarkers for cSVD and other neurodegenerative disorders.

neuroscience↗

bioRxiv2024

Construction of Discrete Element Model of Different Moisture Hygroscopic Fertilizer Particles and Fertilizer Discharging Verification

The hygroscopic fertilizer particles were characterized based on discrete element simulation, and its accuracy was verified by the simulation of fertilizer discharge. Firstly, the repose angle of the fertilizer particles served as the key metric for assessment. A mathematical model characterizing the relationship between fertilizer moisture content and the repose angle was established, R2=0.9935; and a mathematical representation of the repose angle for fertilizer moisture content was established, R2=0.9933. Then, the moisture absorbing fertilizer particles was developed utilizing the integrated Hertz Mindlin with JKR model within EDEM system to account for particle adhesion; A robust correlation model between the repose angle of hygroscopic fertilizers and the discrete element method was established, p <0.0001; Finally, a correlation model between moisture content and significant parameters within the discrete element method was established, drawing upon the models for moisture content repose angle and repose angle discrete element parameters. The moisture-absorbing fertilizer particles model at moisture contents of 2% and 6% were resolved, with a relative error of the repose angle not exceeding 1.42% and a single circle fertilizer discharge error below 8.32%. The results show that the moisture content discrete element significant parameter correlation model can reliably and precisely forecast the discrete element parameters of various moisture content hygroscopic fertilizers. The hygroscopic fertilizer particle model can represent surface interaction characteristics of hygroscopic fertilizer granules. which has guiding significance for the design of precision fertilizer discharge technology device.

physiology↗

bioRxiv2022

Exploring the emergence of morphological asymmetries around the brain's Sylvian fissure: a longitudinal study of shape variability in preterm infants.

Brain folding patterns vary within the human species, but some folding properties are common across individuals, including the Sylvian fissures inter-hemispheric asymmetry. Contrarily to the other brain folds (sulci), the Sylvian fissure develops through the process of opercularization, with the frontal, parietal and temporal lobes growing over the insular lobe. Its asymmetry may be related to the leftward functional lateralization for language processing, but the time-course of these asymmetries development is still poorly understood. In this study, we investigated refined shape features of the Sylvian fissure and their longitudinal development in 71 infants born extremely preterm (mean gestational age at birth: 26.5 weeks) and imaged once before and once at term-equivalent age (TEA). We additionally assessed asymmetrical sulcal patterns at TEA in the perisylvian and inferior frontal regions, neighbor to the Sylvian fissure. While reproducing renown strong asymmetries in the Sylvian fissure, we captured an early encoding of its main asymmetrical shape features, and we observed global asymmetrical shape features representative of a more pronounced opercularization in the left-hemisphere, contrasting with the previously reported right-hemisphere advance in sulcation around birth. This added novel insights about the processes governing early-life brain folding mechanisms, potentially linked to the development of language-related capacities. Highlights- Shape features can be isolated to describe quantitatively the development of the Sylvian fissure - Strong asymmetries are encoded as soon as 30 weeks of post-menstrual age - The process of opercularization is more pronounced in the left hemisphere

neuroscience↗