bioRxiv Science⌕ Search

Biology subjects

Sullivan, C. M.

Publications and source records attributed to Sullivan, C. M..

2 recordsLinked to original sources

A Convolutional Neural Network and R-Shiny App for Automated Identification and Classification of Animal Sounds

The use of passive acoustic monitoring in wildlife ecology has increased dramatically in recent years as researchers take advantage of improvements in automated recording units and associated technologies. These technologies have allowed researchers to collect large quantities of acoustic data which must then be processed to extract meaningful information, e.g. target species detections. A persistent issue in acoustic monitoring is the challenge of processing these data most efficiently to automate the detection of species of interest, and deep learning has emerged as a powerful approach to achieve these objectives. Here we report on the development and use of a deep convolutional neural network for the automated detection of 14 forest-adapted species by classifying spectrogram images generated from short audio clips. The neural network has improved performance compared to models previously developed for some of the target classes. Our neural network performed well for most species and at least satisfactory for others. To improve portability and usability by field biologists, we developed a graphical interface for the neural network that can be run through RStudio using the Shiny package, creating a highly portable solution to efficiently process audio data closer to the point of collection and with minimal delays using consumer-grade computers.

bioinformatics↗

Impact of different intensities of intermittent theta burst stimulation on the cortical properties during TMS-EEG and working memory performance

IntroductionIntermittent theta burst stimulation (iTBS) is a non-invasive brain stimulation technique capable of increasing cortical excitability beyond the stimulation period. Due to the rapid induction of modulatory effects compared to conventional repetitive transcranial magnetic stimulation (rTMS) paradigms, prefrontal application of iTBS is gaining popularity as a therapeutic tool for psychiatric disorders such as depression. In an attempt to increase efficacy, higher than conventional intensities are currently being applied. The assumption that this increases neuromodulatory effect is well established for the standard rTMS paradigms but may be mechanistically false for iTBS. This study examined the influence of intensity on the neurophysiological and behavioural effects of iTBS in the prefrontal cortex.\n\nMethods16 healthy participants received iTBS over prefrontal cortex (F1 electrode) at either 50, 75 or 100% resting motor threshold (rMT) in separate sessions. Single-pulse TMS and concurrent electroencephalography (EEG) was used to assess changes in cortical reactivity measured as TMS-evoked potentials (TEPs) and TMS-evoked oscillations. The n-back task (2-back and 3-back) were used to assess changes in working memory (accuracy and reaction time).\n\nResultsThe data can be summarised as an inverse U-shape relationship between intensity and iTBS plastic effects, where 75% iTBS resulted in the largest neurophysiological changes both in TMS-EEG and working memory. Even though 75% iTBS showed significantly decreased reaction time in the 3-back task, between condition comparisons revealed no significant differences.\n\nConclusionsThe assumption that higher intensity results in greater neuromodulatory effects is false, at least in healthy individuals, and should be carefully considered for clinical populations. Neurophysiological changes associated with working memory following iTBS suggest functional relevance. However, the effects of different intensities on behavioural performance remain elusive in the present healthy sample.\n\nHighlightsO_LIEffects of prefrontal iTBS at 50, 75 and 100% rMT were investigated\nC_LIO_LIInverse U-shape relationship between intensity and neurophysiological effects\nC_LIO_LIEffects on the behavioural performance remain elusive in healthy individuals\nC_LI\n\nDisclosures and conflict of interestsSWC was supported by a Monash Graduate Scholarship. NCR is supported by a NHMRC Early Career Fellowship (1072057). KEH is supported by a NHMRC Career Development Fellowship (1082894). PBF is supported by a NHMRC Practitioner Fellowship (1078567). PBF has received equipment for research from MagVenture A/S, Medtronic Ltd, Cervel Neurotech and Brainsway Ltd and funding for research from Neuronetics and Cervel Neurotech. He is on the scientific advisory board for Bionomics Ltd. There are no other conflicts.

neuroscience↗