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Storrie, B.

Publications and source records attributed to Storrie, B..

2 recordsLinked to original sources

Densely Populated Cell and Organelles Segmentation With Multi-Plane Deep Learning Pipeline

The complex and highly intertwined morphology of activated platelets within blood clot thrombi poses significant challenges for segmentation. Here we develop a robust machine vision pipeline for cell and organelle segmentation within volume electron microscope (vEM) datasets and validate that against both model CREMI neuron segmentation challenge data and focused isotropic FIB-SEM imaged platelets and their organelles within a series of ferric chloride indued murine occlusive clots Neural network predictions were collected along multiple planes, capturing 3D correlations using only 2D neural networks. Using a workstation class computer, we segmented and analyzed hundreds of platelets and report quantitative morphological measurements of platelets and their thousands of included organelles. CREMI neuron segmentation challenge analysis produced state-of-the-art outcomes as did platelet data in comparison to manual segmentation. Our work paves the way for large-scale, single cell, 3D studies across multiple examples and lends initial single cell level insights into occlusive thrombus structure and platelet heterogeneity therein. We include a lightweight Jupyter notebook for initializing and running the neural network (Data and Materials Availability). We also provide Amira Avizo protocols for converting neural network outputs to cell and organelle instances and subsequent morphological measurements.

bioengineering↗

Single-Platelet Mapping of Jugular, Puncture-Wound Thrombi Reveals the Spatial Evolution of Platelet Activation

BackgroundThe contributions of platelet activation to thrombus formation during hemostatic bleeding cessation likely involve multiple activation states. However, the spatial and temporal distribution of platelets in these states has not been defined in a clot. ObjectivesTo use single-platelet mapping of activation states within jugular vein puncture thrombi to determine how the spatial distribution of platelet state evolves during hemostasis. MethodsMontaged, wide-area electron micrographs (EM) were taken at various time points, post-puncture, and annotated for platelet activation state. These classifications were mapped onto the images to identify regions of platelet activation and calculate neighbor associations. The importance of -granule secretion was tested using VAMP8-/- mice. Resultsmapping of platelet activation states at 1 min post-puncture showed extensive spatial intermixing of most platelet activation classes. No high-activation-state, platelet-rich core was observed in 5-min post-puncture thrombi, rather such platelets tended to be localized on the interior surfaces of thrombus vaults open to the circulation. Only at a later stage, 20 min post-puncture, was distinct clustering of high activation, degranulated, cytosol-rich platelets observed. These clusters localized to the central portion of the intravascular platelet-rich crown, and they were now inaccessible to the circulation. Counterintuitively, deletion of the primary platelet v-SNARE, VAMP8, increased the frequency and spatial clustering of highly activated, degranulated platelets in association with intra-thrombus vault surfaces at 5 min post puncture. ConclusionsWe conclude recent multi-activation state models can provide a realistic thrombus formation framework if linked together to encompass the dynamics of puncture wound formation.

systems biology↗