bioRxiv Science⌕ Search

Biology subjects

Souza, F. S.

Publications and source records attributed to Souza, F. S..

2 recordsLinked to original sources

FRAGMENTED BIODIVERSITY: FERNS AND LYCOPHYTES FROM FOREST FRAGMENTS IN JUIZ DE FORA, MINAS GERAIS, BRAZIL

The Atlantic Forest is one of the most threatened formations in the world. In this context, the urbanization process stands out as one of the major factors causing environmental degradation, mainly due to the loss of native vegetation and habitat destruction. In order to fill this gap, we carried out the inventory of ferns and lycophytes in the forest remnants of the municipality of Juiz de Fora. We analyzed more than 1,353 samplings recorded throughout approximately 150 years, as result we recorded a total of 174 species distributed in 73 genera and 26 families. The most representative families were Pteridaceae with 32 species, followed by Polypodiaceae with 26 and Thelypteridaceae with 20. In addition, we present the historical data on the sampling of ferns and lycophytes, as well as the history of the fragmentation process of the Atlantic Forest remnants in the municipality. Juiz de Fora becomes an interesting model for broader floristic studies, generating subsequent subsidies for conservation actions and preservation of the natural patrimony.

plant biology↗

Blocking IL-10 signaling with soluble IL-10 receptor restores specific lymphoproliferative response in dogs with leishmaniasis caused by Leishmania infantum

rIL-10 plays a major role in restricting exaggerated inflammatory and immune responses, thus preventing tissue damage. However, the restriction of inflammatory and immune responses by IL-10 can also favor the development and/or persistence of chronic infections or neoplasms. Dogs that succumb to leishmaniasis caused by L. infantum (CanL) develop exhaustion of T lymphocytes and are unable to mount appropriate cellular immune responses to control the infection. These animals fail to mount specific lymphoproliferative responses and produce interferon gamma and TNF-alpha that would activate macrophages and promote destruction of intracellular parasites. Blocking IL-10 signaling may contribute to the treatment of CanL. In order to obtain a tool for this blockage, the present work endeavored to identify the canine casIL-10R1 amino acid sequence, generate a recombinant baculovirus chromosome encoding this molecule, which was expressed in insect cells and subsequently purified to obtain rcasIL-10R1. In addition, rcasIL-10R1 was able to bind to homologous IL-10 and block IL-10 signaling pathway, as well as to promote lymphoproliferation in dogs with leishmaniasis caused by L. infantum.

immunology↗