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Schrader, B.

Publications and source records attributed to Schrader, B..

2 recordsLinked to original sources

Improving the utility and accuracy of wearable light loggers and optical radiation dosimeters through auxiliary data, quality assurance, and quality control

Wearable light loggers and optical radiation dosimeters are increasingly used in chronobiology and circadian health research, yet their data often lack contextual information (e.g., sleep, activity, environmental conditions) and may be compromised by non-wear periods, compliance issues, or technical faults. To address these limitations, we conducted interviews (n=21) and a survey (n=16) with domain experts to distill and iteratively develop auxiliary data and quality-control strategies aimed at improving the accuracy and interpretability of wearable light measurements. From this process, we established a six-domain auxiliary data framework encompassing wear/non-wear logging, sleep monitoring, light-source context, participant behaviour, user experience, and environmental light levels. Survey responses showed strong consensus on the value of auxiliary information (mean importance 4.0/5), with sleep and wear-time tracking rated as the most essential additions. To support practical adoption, we provide implementation tools, including extensions to the open-source R package LightLogR, enabling streamlined integration of wearable and auxiliary data as well as systematic quality assurance and control. Experts agreed that combining contextual records with rigorous QA/QC procedures substantially improves the reliability of field-collected light-exposure data. These recommendations and tools aim to help researchers in chronobiology, wearable sensing, and health sciences maximise data quality and enhance interpretation in real-world light-exposure studies.

neuroscience↗

Moving Beyond Clinical Risk Scores with a Mobile App for the Genomic Risk of Coronary Artery Disease

Primary prevention of coronary artery disease (CAD) is important for individuals at increased risk, and largely consists of healthy lifestyle modifications and initiation of medications when appropriate - including statins. Defining the inherent risk for any given individual typically relies on traditional risk factors established decades ago by the Framingham Heart Study. Unfortunately, recent studies have indicated that these traditional clinical risk factors systematically overestimate the risk of CAD across all major ancestries. This has increased the number of patients that would be eligible for statin therapy for the primary prevention of CAD but would likely receive little benefit and potentially incur negative consequences. On the other hand, researchers have demonstrated that genetic factors can effectively identify a subset of high risk individuals, and that the benefit from statin therapy is greatest among individuals with the highest genetic risk score (GRS). These individuals also receive the greatest absolute benefit from healthy lifestyle choices, being able to titrate their risk to normal levels despite high genetic predisposition. However, it is not yet possible for the average individual to discover their genetic risk because no tools are currently available to make such a determination. Here, we present a free mobile app - MyGeneRank - that can provide this information. Individuals may choose to use this knowledge to complement traditional risk assessments, and make critical decisions regarding lifelong statin therapy and lifestyle changes. As of 1/25/2017, MyGeneRank is currently in closed beta and will soon be available to the public.

genomics↗