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Biology subjects

Saikia, K.

Publications and source records attributed to Saikia, K..

2 recordsLinked to original sources

Craving Connections: Exploring the Relationship Between Pregnancy Cravings, Maternal Health, and Child Preferences in Indian Families

Although Pregnancy cravings are a common phenomenon, their implications on maternal health, family dietary habits, and child food preferences remain underexplored, particularly in the Indian context. This study aimed to investigate the prevalence and nature of pregnancy cravings among Indian women and their potential impact on maternal health outcomes and family dietary patterns. A cross-sectional survey was conducted with 119 women who had experienced pregnancy, collecting data on craving patterns, maternal health indicators, and perceived influences on family diet. Results revealed that most women craved sugary snacks, predominantly in the second trimester. Notably, 61.9% of participants cravings did not align with their spouses food preferences, suggesting potential shifts in family dietary habits. The study also found associations between cravings, mood swings, and morning sickness, highlighting the complex interplay of physiological and psychological factors during pregnancy. These findings underscore the need for culturally sensitive, personalised prenatal care that address both the nutritional and emotional aspects of pregnancy cravings, influencing long-term family health outcomes.

scientific communication and education↗

Snake venom-inspired novel peptides protect Caenorhabditis elegans against paraquat induced Parkinson's pathology

The in vivo protective mechanisms of two low molecular mass ([~]1.4 kDa) novel custom peptides (CPs) against paraquat (PT)-induced neurodegenerative dysfunction in the Caenorhabditis elegans model were deciphered. CPs prevent the PT binding to the nerve ring adjacent to the pharynx in C. elegans (N2 strain) by stable and high-affinity binding to the tyrosine-protein kinase receptor CAM-1, resulting in significant inhibition of PT-induced toxicity by reducing enhanced reactive oxygen species production, mitochondrial membrane depolarization, and chemosensory dysfunction. The CPs inhibited PT-induced dopaminergic (DAergic) neuron degeneration and alpha-synuclein aggregation, the hallmarks of Parkinsons Disease, in transgenic BZ555 and NL5901 strains of C. elegans. The transcriptomic, functional proteomics, and quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analyses show that CPs prevented the increased expression of the genes involved in the skn-1 downstream pathway, thereby restoring PT-mediated oxidative stress, apoptosis, and neuronal damage in C. elegans. The CPs ability to repair PT-induced damage was demonstrated by a network of gene expression profiles illustrating the molecular relationships between the regulatory proteins. Further, CPs (10 mg/kg, parental route) did not show toxicity or induce inflammatory mediators in the mouse model.

neuroscience↗