Rostami Kandroodi, M. | bioRxiv Science

bioRxiv2021

Cortical dopamine reduces the impact of motivational biases governing automated behaviour

Motivations shape our behaviour: the promise of reward invigorates, while in the face of punishment, we hold back. Abnormalities of motivational processing are implicated in clinical disorders characterised by excessive habits and loss of top-down control, notably substance and behavioural addictions. Striatal and frontal dopamine have been hypothesised to play complementary roles in the respective generation and control of these motivational biases. However, while dopaminergic interventions have indeed been found to modulate motivational biases, these previous pharmacological studies used regionally non-selective pharmacological agents. Here, we tested the hypothesis that frontal dopamine controls the balance between Pavlovian, bias-driven automated responding and instrumentally learned action values. Specifically, we examined whether selective enhancement of cortical dopamine either (i) enables adaptive suppression of Pavlovian control when biases are maladaptive; or (ii) non-specifically modulates the degree of bias-driven automated responding. Healthy individuals (n=35) received the catechol-o-methyltransferase (COMT) inhibitor tolcapone in a randomized, double-blind, placebo-controlled cross-over design, and completed a motivational Go NoGo task known to elicit motivational biases. In support of hypothesis (ii), tolcapone globally decreased motivational bias. Specifically, tolcapone improved performance on trials where the bias was unhelpful, but impaired performance in bias-congruent conditions. These results indicate a non-selective role for cortical dopamine in the regulation of motivational processes underpinning top-down control over automated behaviour. The findings have direct relevance to understanding neurobiological mechanisms underpinning addiction and obsessive-compulsive disorders, as well as highlighting a potential trans-diagnostic novel mechanism to address such symptoms.

neuroscience↗

bioRxiv2021

Optimal Reinforcement Learning with Asymmetric Updating in Volatile Environments: a Simulation Study

AO_SCPLOWBSTRACTC_SCPLOWThe ability to predict the future is essential for decision-making and interaction with the environment to avoid punishment and gain reward. Reinforcement learning algorithms provide a normative way for interactive learning, especially in volatile environments. The optimal strategy for the classic reinforcement learning model is to increase the learning rate as volatility increases. Inspired by optimistic bias in humans, an alternative reinforcement learning model has been developed by adding a punishment learning rate to the classic reinforcement learning model. In this study, we aim to 1) compare the performance of these two models in interaction with different environments, and 2) find optimal parameters for the models. Our simulations indicate that having two different learning rates for rewards and punishments increases performance in a volatile environment. Investigation of the optimal parameters shows that in almost all environments, having a higher reward learning rate compared to the punishment learning rate is beneficial for achieving higher performance which in this case is the accumulation of more rewards. Our results suggest that to achieve high performance, we need a shorter memory window for recent rewards and a longer memory window for punishments. This is consistent with optimistic bias in human behavior.

neuroscience↗