Biology subjects

Romanelli, L.

Publications and source records attributed to Romanelli, L..

2 recordsLinked to original sources

bioRxiv2022

The role of Absorbing Markov Chains in childhood cancer

Absorbing Markov Chains are an important mathematical tool used for different applications in science. On the other hand, cancer and its metastases in children have a significant impact on health due to their degree of lethality. Therefore, the aim of this work is to model the metastatic pathways of the main childhood cancers worldwide. The probabilities of generating metastases, from a primary site to secondary and tertiary sites, were characterized by constructing a directed graph and the associated transition matrix. In addition, the time of absorption and the probabilities of absorption by each absorbing state were calculated.

cancer biology↗

bioRxiv2018

Replicative senescense as a consequence of stochastic processes

The aging of multicellular organisms is a complex problem. It has been the subject of extensive research and have led to various theories. One of the remarkable features of aging is that is accompanied by the decrease in the rate of cell replication in tissue regeneration processes (replicative senescence). In the present work, we will show, if sporadic cell alterations occur in a homogenous set of stem cells, they lengthen the cell cycle and these are fixed with greater probability than non-altered stem cells. This effect is due to the inherent characteristics of the renewal dynamics and as time goes by it leads to a quiescence state for stem cells due to the recurrent fixation of such altered cell.

biophysics↗