Rodrigues, P. L. C. | bioRxiv Science

bioRxiv2023

Harmonizing and aligning M/EEG datasets with covariance-based techniques to enhance predictive regression modeling

Neuroscience studies face challenges in gathering large datasets, which limits the use of machine learning (ML) approaches. One possible solution is to incorporate additional data from large public datasets; however, data collected in different contexts often exhibit systematic differences called dataset shifts. Various factors, e.g., site, device type, experimental protocol, or social characteristics, can lead to substantial divergence of brain signals that can hinder the success of ML across datasets. In this work, we focus on dataset shifts in recordings of brain activity using MEG and EEG. State-of-the-art predictive approaches on M/EEG signals classically represent the data by covariance matrices. Model-based dataset alignment methods can leverage the geometry of covariance matrices, leading to three steps: recentering, re-scaling, and rotation correction. This work explains theoretically how differences in brain activity, anatomy, or device configuration lead to certain shifts in data covariances. Using controlled simulations, the different alignment methods are evaluated. Their practical relevance is evaluated for brain age prediction on one MEG dataset (Cam-CAN, n=646) and two EEG datasets (TUAB, n=1385; LEMON, n=213). When the target sample included recordings from the same subjects with a different task among the same dataset, paired rotation correction was essential ([Formula] (rest-passive) or +0.17 (rest-smt)). When the target dataset included new subjects and a new task, re-centering led to improved performance ([Formula] for rest-passive, [Formula] for rest-smt). For generalization to an independent dataset sampled from a different population and recorded with a different device, re-centering was necessary to achieve brain age prediction performance close to within domain prediction performance. This study demonstrates that the generalization of M/EEG-based regression models across datasets can be substantially enhanced by applying domain adaptation procedures that can statistically harmonize diverse datasets.

neuroscience↗

bioRxiv2023

Methods and considerations for estimating parameters in biophysically detailed neural models with simulation based inference

Biophysically detailed neural models are a powerful technique to study neural dynamics in health and disease with a growing number of established and openly available models. A major challenge in the use of such models is that parameter inference is an inherently difficult and unsolved problem. Identifying unique parameter distributions that can account for observed neural dynamics, and differences across experimental conditions, is essential to their meaningful use. Recently, simulation based inference (SBI) has been proposed as an approach to perform Bayesian inference to estimate parameters in detailed neural models. SBI overcomes the challenge of not having access to a likelihood function, which has severely limited inference methods in such models, by leveraging advances in deep learning to perform density estimation. While the substantial methodological advancements offered by SBI are promising, their use in large scale biophysically detailed models is challenging and methods for doing so have not been established, particularly when inferring parameters that can account for time series waveforms. We provide guidelines and considerations on how SBI can be applied to estimate time series waveforms in biophysically detailed neural models starting with a simplified example and extending to specific applications to common MEG/EEG waveforms using the the large scale neural modeling framework of the Human Neocortical Neurosolver. Specifically, we describe how to estimate and compare results from example oscillatory and event related potential simulations. We also describe how diagnostics can be used to assess the quality and uniqueness of the posterior estimates. The methods described provide a principled foundation to guide future applications of SBI in a wide variety of applications that use detailed models to study neural dynamics. Author summaryA central problem in computational neural modeling is estimating model parameters that can account for observed activity patterns. While several techniques exist to perform parameter inference in special classes of abstract neural models, there are comparatively few approaches for large scale biophysically detailed neural models. In this work, we describe challenges and solutions in applying a deep learning based statistical framework to estimate parameters in a biophysically detailed large scale neural model, and emphasize the particular difficulties in estimating parameters for time series data. Our example uses a multi-scale model designed to connect human MEG/EEG recordings to the underlying cell and circuit level generators. Our approach allows for crucial insight into how cell-level properties interact to produce measured neural activity, and provides guidelines for diagnosing the quality of the estimate and uniqueness of predictions for different MEG/EEG biomarkers.

neuroscience↗