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Pizzoccaro, L.

Publications and source records attributed to Pizzoccaro, L..

2 recordsLinked to original sources

Beyond the straight path: high-density laminar recordings in the ventral hippocampus with curved microprobes

Neural circuits are organized within complex three-dimensional architectures. Most neural interfaces follow linear insertion trajectories, limiting their ability to achieve laminar recording in brain regions where neuronal layers lie approximately parallel to the insertion path. Here, we introduce a curved flexible neural interface that enables near-perpendicular alignment of the recording sites with the targeted neuronal layers. The device consists of a flexible Parylene-C neural probe, integrating 16 PEDOT:BF4-coated Au microelectrodes and a transient silk fibroin stiffener for controlled implantation. The electrodes exhibit low impedance at 1 kHz (29.2 {+/-} 2.5 k{Omega}) and were accurately positioned across the layers of the ventral hippocampus using a rotational implantation strategy. Chronic in vivo recordings demonstrate stable electrochemical performance and reliable acquisition of local field potentials over four weeks. This work establishes a strategy for anatomically matched neural interfacing, enabling high-resolution investigation of neural circuits that are challenging to study with conventional linear probes.

neuroscience↗

Hyperexcitability of female serotonin neurons underlies sex-specific anxiety responses

Mood and anxiety disorders display robust sex differences in prevalence, symptom profile, and treatment outcomes, yet the circuit mechanisms underlying this sex bias remain unclear. Here, we identify a serotonergic (5-HT) pathway from the median raphe region (MRR) to the ventral hippocampus (vHP) that drives sex-specific anxiety regulation in mice. Using a multimodal approach combining electrophysiology, fiber photometry, and optogenetics, we show that vHP-projecting 5-HT neurons (5-HTvHP) in the MRR are intrinsically hyperexcitable in females and exhibit delayed adaptation during exposure to aversive environments. At baseline, female mice displayed greater avoidance and reduced risk-assessment behavior. Optogenetic activation of this pathway selectively enhanced anxiety-like behavior and stress-related grooming in females, while leaving locomotion unaffected. Fiber photometry revealed that grooming episodes coincide with transient suppression of 5-HTvHP activity, suggesting an adaptive feedback mechanism to downregulate serotonergic tone under elevated anxiety. Moreover, activation of this pathway disrupted hippocampal theta dynamics during habituation to a novel arena exclusively in females, revealing serotonergic modulation of anxiety and novelty processing. These results were consistent with the identification of sex-specific M-currents, which constrained excitability in male MRR 5-HTvHP neurons, while being largely absent in females. Collectively, our findings uncover a hyperexcitable MRR-vHP serotonergic circuit that drives female-specific anxiety states, providing a mechanistic framework for understanding sex-specific vulnerability to mood and anxiety disorders.

neuroscience↗