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Pinsk, M.

Publications and source records attributed to Pinsk, M..

2 recordsLinked to original sources

An open resource for nonhuman primate imaging

Non-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational and cross-species comparative neuroscience.\n\nUnfortunately, the technological and methodological advances of the past two decades have outpaced the accrual of data, which is particularly challenging given the relatively few centers that have the necessary facilities and capabilities. The PRIMate Data Exchange (PRIME-DE) addresses this challenge by aggregating independently acquired non-human primate magnetic resonance imaging (MRI) datasets and openly sharing them via the International Neuroimaging Data-sharing Initiative (INDI). Here, we present the rationale, design and procedures for the PRIME-DE consortium, as well as the initial release, consisting of 13 independent data collections aggregated across 11 sites (total = 98 macaque monkeys). We also outline the unique pitfalls and challenges that should be considered in the analysis of the non-human primate MRI datasets, including providing automated quality assessment of the contributed datasets.

neuroscience

Organizing principles of pulvino-cortical connectivity in humans

The pulvinar regulates information transmission to cortex and communication between cortical areas. The way the pulvinar interacts with cortex is governed by its intrinsic organization. Here, we show using fMRI that the human pulvinar is functionally heterogeneous, broadly separated into dorsal and ventral subdivisions based on characterization of response properties and functional connectivity with cortex. These differences mirrored the organization of the dorsal and ventral streams of visual cortex. The ventral subdivision of the pulvinar was functionally coupled with occipital and temporal cortex. The dorsal subdivision of the pulvinar was functionally coupled with frontal and parietal cortex. The dorsal subdivision was also coupled with the human-specific tool network and to the default mode network. The spatial organization of pulvino-cortical coupling reflected both the functional similarities and anatomical distances between cortical areas. Together, the human pulvinar appears to represent the entire visual system and the principles that govern its organization, though in a spatially compressed form.\n\nAuthor ContributionsMA, MP, and JC collected data; MA and JC analyzed the data; MA, MP, JC, and SK wrote the paper.

neuroscience