Biology subjects

Peter, V.

Publications and source records attributed to Peter, V..

3 recordsLinked to original sources

bioRxiv2024

Basophils drive the resolution and promote wound healing in adult and aged mice

An active resolution is critical to control the duration of inflammation and limit its pathological consequences. Defects in resolution during wound healing allow the emergence of chronic wounds, a common complication in the elderly. Here, we show that basophils infiltrate the periphery of mouse skin wounds for at least three weeks, during both the inflammation and resolution phases of wound healing. Depletion of basophils induces an increased secretion of inflammatory molecules, accumulation and activation of pro-inflammatory leukocytes, and delays the wound healing response. Basophils particularly promote epidermal differentiation towards homeostasis in the wounds. Basophil-derived IL-4 and M-CSF drive partly their immunoregulatory and healing properties. Unexpectedly, aged mice basophils infiltrate more potently the wounds to promote inflammation resolution, showing a transcriptomic signature biased towards tissue remodeling. Thus, basophils are not pro-inflammatory but pro-resolution cells during an essential biological process such as skin wound healing. Unraveling basophil pro-resolution properties may reveal new strategies to fight chronic wounds in the elderly. SUMMARYThe resolution of inflammation is essential for homeostasis and becomes defective with age. Here we show basophil immunoregulatory properties promote resolution during skin wound healing, in both adult and aged mice.

immunology↗

bioRxiv2022

Atypical cortical encoding of speech identifies children with Dyslexia versus Developmental Language Disorder

Slow cortical oscillations play a crucial role in processing the speech envelope, which is perceived atypically by children with Developmental Language Disorder (DLD) and developmental dyslexia. Here we use electroencephalography (EEG) and natural speech listening paradigms to identify neural processing patterns that characterize dyslexic versus DLD children. Using a story listening paradigm, we show that atypical power dynamics and phase-amplitude coupling between delta and theta oscillations characterize dyslexic and DLD children groups, respectively. We further identify EEG common spatial patterns (CSP) during speech listening across delta, theta and beta oscillations describing dyslexic versus DLD children. A linear classifier using four deltaband CSP variables predicted dyslexia status (0.77 AUC). Crucially, these spatial patterns also identified children with dyslexia in a rhythmic syllable task EEG, suggesting a core developmental deficit in neural processing of speech rhythm. These findings suggest that there are distinct atypical neurocognitive mechanisms underlying dyslexia and DLD.

neuroscience↗

bioRxiv2021

Disrupting D2-NMDA receptor heteromerization blocks the rewarding effects of cocaine but preserves natural reward processing

Addictive drugs increase dopamine in the nucleus accumbens (NAc), where it persistently shapes excitatory glutamate transmission and hijacks natural reward processing. Herein, we provide evidence, from mice to human, that an underlying mechanism relies on drug-evoked heteromerization of glutamate NMDA receptors (NMDAR) with dopamine receptor 1 (D1R) or 2 (D2R). Using temporally-controlled inhibition of D1R-NMDAR heteromerization, we unraveled their selective implication in early developmental phases of cocaine-mediated synaptic, morphological and behavioral responses. In contrast, preventing D2R-NMDAR heteromerization blocked the persistence of these adaptations. Importantly, interfering with these heteromers spared natural reward processing. Strikingly, we established that D2R-NMDAR complexes exist in human samples and showed that, despite a decreased D2R protein expression in the NAc, psychostimulant-addicts display a higher proportion of D2R forming heteromers with NMDAR. These findings contribute to a better understanding of molecular mechanisms underlying addiction and uncover D2R-NMDAR heteromers as targets with potential therapeutic value.

neuroscience↗