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Biology subjects

Patel, T. S.

Publications and source records attributed to Patel, T. S..

2 recordsLinked to original sources

Prediction of Heart Disease and Survivability using Support Vector Machine and Naive Bayes Algorithm

PurposeIn the present work, we examined the outcomes and accuracy of the Support vector machine (SVM) and the Naive Bayes algorithms on a dataset, to predict whether the patient has heart disease or not, and the patients survival prediction status. MethodThe machine learning procedures were developed using the clinically validated datasets with sixteen attributes from the University of California, Irvines Centre for Machine Learning, and Intelligent Systems. Confusion matrix was used to visualise the accuracy, recall, precision, and error of the models. Statistical analysis was done to prove the model accuracy using the receiver operating characteristic (ROC) curve and area under the curve (AUC). ResultsThe proposed method of heart disease prediction using Naive Bayes had 87 % accuracy. The accuracy for heart survivability models using SVM and Naive Bayes were 88 % and 93 %. The model efficiency for heart survivability using ROC curve with AUC 0.93 for Naive Bayes and AUC 0.91 for SVM. ConclusionSuch prediction systems can help the medical sector to save energy, cost, and time by providing more efficient techniques to forecast decisions with high accuracy. This study will enable the statisticians and researchers to select more efficient and accurate machine learning algorithms to achieve better prediction of the "cardiovascular disease".

bioinformatics↗

SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling

Severe COVID-19 is associated with epithelial and endothelial barrier dysfunction within the lung as well as in distal organs. While it is appreciated that an exaggerated inflammatory response is associated with barrier dysfunction, the triggers of this pathology are unclear. Here, we report that cell-intrinsic interactions between the Spike (S) glycoprotein of SARS-CoV-2 and epithelial/endothelial cells are sufficient to trigger barrier dysfunction in vitro and vascular leak in vivo, independently of viral replication and the ACE2 receptor. We identify an S-triggered transcriptional response associated with extracellular matrix reorganization and TGF-{beta} signaling. Using genetic knockouts and specific inhibitors, we demonstrate that glycosaminoglycans, integrins, and the TGF-{beta} signaling axis are required for S-mediated barrier dysfunction. Our findings suggest that S interactions with barrier cells are a contributing factor to COVID-19 disease severity and offer mechanistic insight into SARS-CoV-2 triggered vascular leak, providing a starting point for development of therapies targeting COVID-19 pathogenesis.

microbiology↗