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Oyler, A. R.

Publications and source records attributed to Oyler, A. R..

2 recordsLinked to original sources

Small language models enable rapid and accurate extraction of structured data from unstructured text: an example with plants and their specialized metabolites

Transformer-based large language models are receiving considerable attention because of their ability to analyze scientific literature. Small language models (SLMs), however, also have potential in this area, have smaller compute footprints, and allow users to keep data in-house. Here, we quantitatively evaluate the ability of SLMs to: (i) score references according to project-specific relevance and (ii) extract and structuring data from unstructured sources (scientific abstracts). By comparing SLMs outputs against those of a human on hundreds of abstracts, we found that (i) SLMs can effectively filter literature and extract structured information relatively accurately (error rates as low as 10%), but not with perfect yield (as low as 50% in some cases), (ii) that there are tradeoffs between accuracy, model size, and computing requirements, and (iii) that clearly written abstracts are needed to support accurate data extraction. We recommend advanced prompt engineering techniques, full-text resources, and model distillation as future directions.

plant biology↗

A new spin on chemotaxonomy using non-proteogenic amino acids as a test case

PremiseSpecialized metabolites serve various roles for plants and humans. Unlike core metabolites, specialized metabolites are restricted to certain lineages. Thus, in addition to their ecological functions, specialized metabolites can serve as diagnostic markers of plant lineages. MethodsWe investigate the phylogenetic distribution of plant metabolites using non-proteogenic amino acids (NPAA). Species-NPAA associations for eight NPAAs were identified from the existing literature and placed within a phylogenetic context using R packages and interactive tree of life. To confirm and extend the literature-based NPAA distribution we selected azetidine-2-carboxylic acid (Aze) and screened over 70 diverse plants using GC-MS. ResultsLiterature searches identified > 900 NPAA-relevant articles, which were manually inspected to identify 560 species-NPAA associations. NPAAs were mapped at the order and genus level, revealing that some NPAAs are restricted to single orders, whereas others are present across divergent taxa. The distribution of Aze across plants suggests a convergent evolutionary history. DiscussionThe reliance on chemotaxonomy has decreased over the years. Yet, there is still value in placing metabolites within a phylogenetic context to understand the evolutionary processes of plant chemical diversification. This approach can be applied to metabolites present in any organism and compared at a range of taxonomic levels.

plant biology↗