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Otsuka, T.

Publications and source records attributed to Otsuka, T..

2 recordsLinked to original sources

Near-optimal integration of the magnitude Information of time and numerosity

Magnitude information is often correlated in the external world, providing complementary information about the environment. As if to reflect this relationship, the perceptions of different magnitudes (e.g., time and numerosity) are known to influence one another. Recent studies suggest that such magnitude interaction is similar to cue integration, such as multisensory integration. Here, we tested whether human observers could integrate the magnitudes of two quantities with distinct physical units (i.e., time and numerosity) as abstract magnitude information. The participants compared the magnitudes of two visual stimuli based on time, numerosity, or both. Consistent with the predictions of the maximum likelihood estimation (MLE) model, the participants integrated time and numerosity in a near-optimal manner; the weights for numerosity increased as the reliability of the numerosity information increased, and the integrated estimate was more reliable than either the time or numerosity estimate. Furthermore, the integration approached a statistical optimum as the temporal discrepancy of the acquisition of each piece of information became smaller. These results suggest that magnitude interaction arises through a similar computational mechanism to cue integration. They are also consistent with the idea that different magnitudes are processed by a generalized magnitude system.

neuroscience↗

Castration alters the circadian clock and Ucp1 expression in subcutaneous white adipose tissue of mice

Castration increases the risk of metabolic syndromes in mammals. In addition, recent studies have demonstrated that castration increases the expression of Ucp1 in subcutaneous white adipose tissue (scWAT). However, how castration leads to thermogenic aberration remains poorly understood. Here, we found that castrated mice showed elevated Ucp1 expression in scWAT in response to cold exposure with an increase in body temperature in the light phase and a reduction in body weight gain with fat reduction despite showing no alterations in food intake, locomotor activity in a novel environment, and gastrocnemius muscle weight. We also analyzed the circadian behavioral rhythm and the expression rhythm of clock genes in the suprachiasmatic nucleus (SCN) and scWAT. We found that castrated mice showed fluctuations in circadian locomotor activity and a decrease in the expression rhythm of clock genes in the SCN (clock) and scWAT (Bmal1 and Per2). Moreover, the expression of Ucp1 in scWAT was rhythmic, and it was increased in castrated mice, while the expression of clock genes was decreased. These results indicate that castration may impact browning in scWAT through variations in the circadian clock and Ucp1 expression.

physiology↗