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Ogasawara, S.

Publications and source records attributed to Ogasawara, S..

2 recordsLinked to original sources

Crowdsourced Wildlife Observations Uncover Ecotourism Assets-Sites and Species

Ecotourism plays a vital role in conserving ecosystems and revitalising rural economies. Sustainable management requires strategies that effectively balance conservation needs with tourism promotion, necessitating a clear understanding of which landscapes and species attract visitors. However, identifying these "charismatic" assets has traditionally relied on costly and spatially limited surveys. This study leverages crowdsourced biodiversity data from digital platforms (iNaturalist and Biome) to identify nature-based recreation sites and visitor-preferred species in Inabe City, a rural Japanese municipality with high recreational visitation. We analysed 12,764 observations within the city and 238,625 reference observations from across Japan. By applying the Out-of-Area Activity Index (OAAI) to biological recording data, we distinguished visitors from residents with high accuracy. Spatial analyses using hurdle models revealed distinct preferences: while both groups frequented recreational facilities, residents concentrated on lowland forests, whereas visitors were significantly drawn to wetlands and mountain habitats. To quantify specific biological interests, we developed the Visitor Preference Index (VPI). This index highlighted that visitors disproportionately recorded aquatic insects (e.g., dragonflies) and endangered understory plants compared to their observations elsewhere, identifying these taxa as key ecological assets. These findings underscore the critical importance of managing highland forests and wetlands--habitats often vulnerable to degradation--to support both biodiversity and tourism. This study illustrates how crowdsourced biodiversity data can contribute to understanding human-nature interactions and offer a scalable tool for regional planning that integrates ecological conservation with sustainable tourism development.

ecology↗

Structural basis of anticancer drug recognition and amino acid transport by LAT1

LAT1 (SLC7A5) transports large neutral amino acids and their derivatives across the plasma membrane and plays pivotal roles in cancer cell proliferation, immune response and drug delivery across the blood-brain barrier. Despite recent advances in structural understanding of LAT1, how it discriminates substrates and inhibitors including the clinically relevant anticancer drugs remains elusive. Here we report six structures of LAT1, captured in three different conformations and bound with diverse bioactive ligands, elucidating its substrate transport and inhibitory mechanisms. JPH203, also known as nanvuranlat or KYT-0353 and currently in clinical trials as an anticancer drug, binds to the wide-open substrate-binding pocket of LAT1. It adopts a U-shaped conformer, with its amino-phenylbenzoxazol moiety pushing against transmembrane helix 3 (TM3), bending TM10 and arresting the transporter in the outward-facing conformation. In contrast, the physiological substrate L-Phe does not exhibit such inhibitory interactions, whereas melphalan, a slow substrate, poses steric hindrance in the pocket, explaining its inhibitory activity. Unexpectedly, the "classical" system L inhibitor BCH induces an occluded state, a key structural intermediate required for substrate transport. Trans stimulation assays show that BCH facilitates transporter turnover and is therefore a transportable substrate. These findings provide a structural framework for the intricate mechanisms of substrate recognition and inhibition of LAT1, paving the way for developing more specific and effective drugs against it.

biochemistry↗