Moosavi-Movahedi, A. A. | bioRxiv Science

bioRxiv2025

Musical Insights into Protein Sequences and Functions via NMR Data

This study explores an innovative technique for transforming rhythmic patterns found in nature into music, with a focus on protein sequences. For the past twenty years, various strategies have been developed for musical translation of biological sequences. This research presents a groundbreaking approach where music is derived from protein nano-scale structures using the atomic frequencies of amino acids extracted from NMR experiments. Each amino acid is assigned a unique musical note and duration, determined by its 13CNMR spectrum and relaxation period. Applying this method, music was composed from different protein sequences, including homologue {beta}-globin, where a set theory-based comparative analysis was conducted. This novel approach opens up a new auditory dimension for understanding protein functions.

bioinformatics↗

bioRxiv2022

Sturgeons: An Evolutionary Insight to The α-globin Protein Speciation and Diversification

Sturgeons are living fossils and among the oldest surviving vertebrate species, and Caspian Sea is habitat of the vast majority of sturgeon species. It is tempting to assume that speciation of sturgeons occurred in response to the severe environmental changes during the formation of Caspian Sea from the ancient Paratethys Sea. Hemoglobin (Hb) reflects the evolutionary history of fishes. Changes in the Hb sequences will affect the protein structure and consequently the vital function of oxygen delivery. As complete sequence data for any sturgeon hemoglobin gene or protein was hitherto not available, we determined the complete gene and protein sequences of an -globin chain (as one of the constituents of Hb complex) from six Caspian Sea sturgeons of different species and compared these sequences mutually and with all available fish -globin sequences. The phylogenetic analyses based on alpha globin sequences can highlight the essentiality of proper changes in globin chains in the speciation process. Estimating the divergence time of -globin genes for different fish families discloses important facts about the rate of evolution and decodes. The results support the hypothesis of simultaneity between the time of morphological speciation of fish families and their -globin divergence. The correlation and concurrency between morphological and molecular changes can be interpreted as a sign of struggling to acquire more fitness to changing environment.

evolutionary biology↗