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Biology subjects

Momeny, M.

Publications and source records attributed to Momeny, M..

4 recordsLinked to original sources

A multimodal learning approach for automated detection of wildlife trade on social media

Social media data and machine learning methods for automated content analysis are increasingly being used in ecology and conservation science. A current limitation is the lack of methods for automated multimodal analysis of textual and visual content among other data modalities. In this study, we introduce a multimodal content analysis method applied to the investigation of wildlife trade on YouTube. Our approach consists of analyzing text through transformer based neural networks and video keyframes using convolutional neural networks as part of multimodal filtering followed by classification where a decision fusion module identifies instances of wildlife trade. The decision fusion module achieved an F-score of 0.72 among textual classifiers for trade detection and of 0.77 among visual classifiers for species identification. This multimodal classification helped detect wildlife trade in 3,715 out of 86,321 filtered YouTube posts, featuring 226 species for sale, including 51 Critically Endangered, 62 Endangered, 60 Vulnerable, 25 Near Threatened, and 28 Least Concern species. The proposed multimodal learning methods can be used more broadly for other ecological and biodiversity conservation applications. The bigger pictureThe unsustainable trade in wildlife is a major driver of biodiversity loss, threatening thousands of species across the Tree of Life. While online platforms have become popular spaces for advertising wildlife and exotic pets for sale, monitoring these platforms remains extremely challenging. Traditional surveillance methods are not scalable, and automated tools have typically focused on either text or image analysis in isolation, limiting their effectiveness in identifying nuanced instances of wildlife trade. Our study introduces a multimodal machine learning framework that integrates textual and visual data to detect potential wildlife trade on YouTube. By combining natural language processing with deep learning for image analysis, and filtering millions of posts down to those most relevant, our method significantly improves detection accuracy. This dual-layered approach uncovered thousands of posts featuring hundreds of species, many of which are threatened. This work demonstrates how advances in machine learning can support ecological monitoring and conservation by providing timely, data-driven, insights into online trade networks. In the pursuit of reducing biodiversity loss, this study offers an approach for bridging the gap between online behavior and real-world ecological outcomes. HighlightsO_LIIntroduces a multimodal content analysis approach for detecting wildlife trade on YouTube by integrating textual and visual data. C_LIO_LIA multimodal filtering technique reduces irrelevant text and video content, enhancing analytical efficiency. C_LIO_LIA decision fusion module then combines results from text and video filtering improving wildlife trade detection accuracy. C_LIO_LIThe proposed methods are applicable across multiple online platforms and suitable for diverse tasks in ecology and biodiversity conservation. C_LI

ecology↗

Somatostatin Receptor 2 Overexpression in Hepatocellular Carcinoma: Implications for Cancer Biology and Theranostic Applications

(1) BackgroundSomatostatin receptor 2 (SSTR2) is overexpressed in various tumors, including hepatocellular carcinoma (HCC), yet its role in tumorigenesis remains unclear. This study examines the roles of SSTR2 in the molecular pathology of HCC and explores its potential as a target for SSTR2-directed radiopharmaceuticals in this malignancy. (2) MethodsSSTR2 expression was analyzed across 22 malignancies using TNMplot and specifically in HCC through The Human Protein Atlas. Transcriptomic data, protein expression, and copy number alterations in HCC patients with varying SSTR2 levels were compared using The Cancer Genome Atlas (TCGA). Gene Ontology (GO) enrichment analysis was performed using SRplot, while survival analysis was conducted with GEO datasets. (3) ResultsMost HCC patients exhibit moderate levels of SSTR2 expression. Elevated SSTR2 expression is associated with worse overall and disease-specific survival, as well as the activation of pathways involved in tumor growth and metastasis. Furthermore, SSTR2 expression is linked to key oncogenes and receptor tyrosine kinases. (4) ConclusionsSSTR2 in HCC signifies an oncogenic network and represents a promising therapeutic target to inhibit tumor invasion and serve as a theranostic biomarker. HCC patients with elevated SSTR2 expression could benefit from SSTR2-targeted theranostics, enabling enhanced tumor detection and more effective therapy.

cancer biology↗

SSTR2-targeted theranostics in hepatocellular carcinoma

(1) BackgroundWhile the clinical use of radiolabeled somatostatin analogs is established in neuroendocrine tumors, there is significant interest in expanding their use for other somatostatin receptor 2 (SSTR2)-expressing cancers. This study investigates the utility of SSTR2-targeted theranostics in hepatocellular carcinoma (HCC); (2) MethodsWe measured SSTR2 expression in HCC cell lines and clinical samples using qRT-PCR, Western blot, and a public dataset. We evaluated [67Gallium]Ga-DOTATATE uptake, tested [177Lutetium]Lu-DOTATATE cytotoxicity, and assessed [68Gallium]Ga-DOTATATE tumor targeting in HCC animal models and a patient via PET/CT; (3) ResultsSSTR2 expression was confirmed in HCC cell lines and clinical samples. Radioligand uptake studies validated SSTR2-mediated [67Gallium]Ga-DOTATATE uptake, and [177Lutetium]Lu-DOTATATE treatment reduced cell proliferation. [68Gallium]Ga-DOTATATE PET/CT scans detected tumors in animal models and spinal metastases in a patient with HCC; (4) ConclusionThese findings suggest for the first time that SSTR2-based theranostics could have strong implications for detection and treatment of HCC. Simple SummaryThis study investigates the use of SSTR2-targeted theranostics, combining diagnostic and therapeutic approaches, in hepatocellular carcinoma (HCC). We confirmed significant SSTR2 expression in HCC cells and patient samples, showing that radiolabeled compounds such as [67Ga]Ga-DOTATATE and [177Lu]Lu-DOTATATE, commonly used in neuroendocrine tumors, could also target HCC. In preclinical models and a patient case, PET/CT imaging and treatments demonstrated effective tumor detection and shrinkage. These findings suggest that SSTR2-targeted theranostics could offer a novel, targeted method for diagnosing and treating HCC, potentially improving outcomes for patients with this challenging cancer.

cancer biology↗

Transcriptional landscape of DTP-DTEP transition reveals DUSP6 as a driver of HER2 inhibitor tolerance via Neuregulin/HER3 axis

The mechanisms promoting re-growth of dormant cancer cells under continuous tyrosine kinase inhibitor (TKI) therapy are poorly understood. Here we present transcriptional profiling of HER2+ breast cancer cells treated continuously with HER2 TKI (HER2i) therapy for 9 months. The data reveals specific gene regulatory programs associated with transition from dormant drug tolerant persister cells (DTPs) to proliferating DTEP (drug tolerant expanding persister) cells and eventually long-term resistance. Focusing on yet poorly understood phosphatases as determinants of therapy tolerance, expression of dual-specificity phosphatase DUSP6 was found inhibited in DTPs, but strongly induced upon re-growth of DTEPs. DUSP6 overexpression conferred apoptosis resistance whereas its pharmacological blockade prevented DTEP development under HER2i therapy. The DUSP6-driven HER2i tolerance was mediated by activation of neuregulin-HER3 axis, and consistent with the role of HER3 in widespread therapy tolerance, DUSP6 targeting also synergized with clinically used HER2i combination therapies. In vivo, pharmacological DUSP6 targeting induced synthetic lethal effect with HER2i in independent tumor models, and its genetic targeting reduced tumor growth in orthotopic brain metastasis model. Collectively this work provides first transcriptional landscape of DTP-DTEP transition under TKI therapy, and identify DUSP6 as a novel candidate therapy target to overcome widespread HER3-driven therapy resistance.

cancer biology↗