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Mezo, G.

Publications and source records attributed to Mezo, G..

2 recordsLinked to original sources

Ancient genomes reveal Avar-Hungarian transformations in the 9-10th centuries CE in the Carpathian Basin

During the Early Medieval period, the Carpathian Basin witnessed significant demographic shifts, notably under the Avar dominance for approximately 250 years, followed by the settlement of early Hungarians in the region during the late 9th century CE. This study presents the genetic analysis of 296 ancient samples, including 103 shotgun-sequenced genomes, from present-day Western Hungary. By employing identity-by-descent (IBD) segment sharing networks, this research offers detailed insights into the population structure and dynamics of the region from the 5th to the 11th centuries CE, with specific focus on certain microregions. Our evaluations reveal spatially different histories in Transdanubia even between communities in close geographical proximity, highlighting the importance of dense sampling and analyses. Our findings highlight extensive homogenisation and reorganization processes, discontinuities between Hun, Avar, and Conquest period immigrant groups, alongside the spread and integration of ancestry related to the Hungarian conquerors. TeaserGenetic formation of medieval Hungary, discontinuity between immigrant groups in the first millennium CE

genomics↗

Fundamental Role Of The H2A.Z C-Terminal Tail In The Formation Of Constitutive Heterochromatin

H2A.Z-nucleosomes are present in both euchromatin and heterochromatin and it has proven difficult to interpret their disparate roles in the context of their stability features. Using an in situ assay of nucleosome stability and DT40 cells expressing engineered forms of the histone variant we show that native H2A.Z, but not C-terminally truncated H2A.Z (H2A.Z{Delta}C), is released from nucleosomes of peripheral heterochromatin at unusually high salt concentrations. H2A.Z and H3K9me3 landscapes are reorganized in H2A.Z{Delta}C-nuclei and overall sensitivity of chromatin to nucleases is increased. These tail-dependent differences are recapitulated upon treatment of HeLa nuclei with the H2A.Z-tail-peptide (C9), with MNase sensitivity being increased at specific regions including promoters. Introduced into live cells C9 elicits down-regulation of [~]560 genes with nonrandom chromosomal band-localization and pathway-spectrum. Thus, tail-dependent heterogeneity of H2A.Z-nucleosomes is revealed at all organization levels of chromatin and epigenetic modulation can be achieved by targeting molecular interactions involving its C-terminal tail.

cell biology↗