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Merz, J.

Publications and source records attributed to Merz, J..

2 recordsLinked to original sources

Small-scale fen restoration brings back key species and ecosystem functions

O_LIFen peatlands act as carbon sinks and are hotspots for specialised species, but a large proportion of fens have been drained for agricultural or forestry use. Drainage turns peatlands from carbon sink to carbon source, and negatively affects specialised biodiversity. Although restoration by rewetting can partially improve ecosystem functions, the successful recovery of specialised biota depends on previous land use. Rewetting agriculturally used fens often results in an ecosystem that does not resemble the original fen. The vegetation recovery of rewetted fens used for forestry is more promising, but our knowledge of vegetation development comes from boreal fens. It is unclear whether vegetation can successfully recover after the rewetting of forestry-drained fens in the temperate zone. C_LIO_LIOur study focused on the recovery of vegetation and peat accumulation in small fens in temperate Europe, located in a large forest complex in Germany, that had been drained for forestry and restored by rewetting over the 38 years prior to the study. We compared the restored sites to degraded and near-natural ones. We recorded vegetation composition and measured peat depth. C_LIO_LIWe demonstrate that peat layers continuously increased with time since restoration, possibly indicating peat accumulation, which is crucial for converting drained fens back into carbon sinks. The vegetation composition of the restored sites became increasingly similar to that of the near-natural sites over time, with the steepest change occurring during the first 10 years after restoration. Nevertheless, even after decades, the vegetation did not reach the quality of near-natural sites. C_LIO_LISynthesis and applications: Our results highlight that rewetting forestry-drained temperate fens can lead to partial vegetation recovery and jump-start peat formation. C_LI

ecology↗

Display of malaria transmission-blocking antigens on chimeric DHBV-derived virus-like particles produced in Hansenula polymorpha

1.BackgroundMalaria caused by Plasmodium falciparum is one of the major threats to human health globally. Despite huge efforts in malaria control and eradication, highly effective vaccines are urgently needed, including vaccines that can block malaria transmission. Chimeric virus-like particles (VLP) have emerged as a promising strategy to develop new malaria vaccine candidates.\n\nMethodsWe developed yeast cell lines and processes for the expression of malaria transmission-blocking vaccine candidates Pfs25 and Pfs230 as VLP and VLP were analyzed for purity, size, protein incorporation rate and expression of malaria antigens.\n\nResultsIn this study, a novel platform for the display of Plasmodium falciparum antigens on chimeric VLP is presented. Leading transmission-blocking vaccine candidates Pfs25 and Pfs230 were genetically fused to the small surface protein (dS) of the duck hepatitis B virus (DHBV). The resulting fusion proteins were co-expressed in recombinant Hansenula polymorpha (syn. Pichia angusta, Ogataea polymorpha) strains along with the wild-type dS as the VLP scaffold protein. Through this strategy, chimeric VLP containing Pfs25 or the Pfs230-derived fragments Pfs230c or Pfs230D1M were purified. Up to 100 mg chimeric VLP were isolated from 100 g dry cell weight with a maximum protein purity of 90 % on the protein level. Expression of the Pfs230D1M construct was more efficient than Pfs230c and enabled VLP with higher purity. VLP showed reactivity with transmission-blocking antibodies and supported the surface display of the malaria antigens on the native VLP.\n\nConclusionThe incorporation of leading Plasmodium falciparum transmission-blocking antigens into the dS-based VLP scaffold is a promising novel strategy for their display on nano-scaled particles. Competitive processes for efficient production and purification were established in this study.

synthetic biology↗