Mehaffey, W. H. | bioRxiv Science

bioRxiv2021

Heritable differences in synaptic zinc-transporter levels drive variation in learned birdsong

The authors have withdrawn this manuscript. During revision of our manuscript, we carried out several lines of additional experiments and analyses that failed to fully support and reproduce the results previously presented in Figure 4 (regarding potential mechanisms whereby zinc and SLC39all contribute to song tempo). We therefore do not want this result to be cited and are withdrawing our paper while we carry out additional experiments to clarify potential contributions of SLC39all to individual variation in song tempo. We apologize for any inconvenience caused to our readers. Any questions can be addressed to DGM (first/corresponding author) and/or MSB (last/senior author).

neuroscience↗

bioRxiv2018

A polymer probe-based system for high density, long-lasting electrophysiological recordings across distributed neuronal circuits

The brain is a massive neuronal network, organized into anatomically distributed sub-circuits, with functionally relevant activity occurring at timescales ranging from milliseconds to months. Current methods to monitor neural activity, however, lack the necessary conjunction of anatomical spatial coverage, temporal resolution, and long-term stability to measure this distributed activity. Here we introduce a large-scale, multi-site recording platform that integrates polymer electrodes with a modular stacking headstage design supporting up to 1024 recording channels in freely behaving rats. This system can support months-long recordings from hundreds of well-isolated units across multiple brain regions. Moreover, these recordings are stable enough to track 25% of single units for over a week. This platform enables large-scale electrophysiological interrogation of the fast dynamics and long-timescale evolution of anatomically distributed circuits, and thereby provides a new tool for understanding brain activity.

neuroscience↗