Biology subjects

Martynov, A. V.

Publications and source records attributed to Martynov, A. V..

3 recordsLinked to original sources

bioRxiv2021

Cryptic survival and an unexpected recovery of the long-tailed mayfly Palingenia longicauda (Olivier, 1791) (Ephemeroptera: Palingeniidae) in Southeastern Europe.

O_LIOnce widespread in the large European rivers, Palingenia longicauda underwent a drastic range contraction as a result of the intense pollution and hydromorphological interventions of the 19th and 20th centuries. For the last decades it was considered to be restricted only to the Tisa River and its tributaries, and to the Raba River, but new reports indicated its presence in the Danube River in Hungary, in the Danube Delta in Romania and Ukraine, and in the Prut River in the Republic of Moldova. C_LIO_LIThe objective of this study is to analyze the phylogeographic pattern between the two main eco-regions (Pannon and Pontic) of the species distribution, based on the combined mitochondrial COI (472 bp) and 16S (464 bp) sequences generated for individuals collected in Romania and Ukraine, and from publicly available ones, representing the Tisa catchment populations. C_LIO_LIThe presence of viable populations in the Danube Delta and on the Prut River in Romania is confirmed, and additional presence on the Mure{square} and Bega rivers from Romania, and on the Styr and Horyn rivers in Northern Ukraine is shown. C_LIO_LIThe phylogeographic results indicate that the presence of the analyzed populations are not the result of recent founding events from the Pannon region, confirming the survival and expansion of cryptic local lineages. C_LIO_LIThe recent recovery of the species may be related to the improvement of water quality as a result of the implementation of the EU Water Framework Directive and the EU Floods Directive after 2000. C_LI

ecology↗

bioRxiv2019

Pharmacological efficacy of a synergistic composition based on activators of cAMP accumulation as a wound healing agent

IntroductionWound-healing dipyridamole- and papaverine-based aerosols (D1/D2) as activators of the accumulation of cyclic adenosine monophosphate are promising drugs that can accelerate wound healing in wound processes of various origins.\n\nMaterials and methods128 rats were used in the study, including 38 in a pharmacological experiment on a model of stencil wounds and 90 in an experiment that studied the effect of spray on the number of CD34 cells in the blood of rats with chemically induced immunodeficiency. Immunodeficiency was caused by the fivefold administration of cyclophosphamide and prednisone. The expression level of CD34 was determined using flow cytofluorimeter.\n\nResults and discussionTopical application of D1/D2 aerosol samples on the skin of rats contributed to a statistically significant acceleration of regeneration processes. In terms of the appearance of granulations and epithelialization of wounds, D1/D2 aerosols were superior to dexpanthenol ointment. The maximum effect from the use of D1/D2 was observed on the 60th day, and restoration of the physiological level of pluripotent cells was observed as early as on the 10th day after the start of spray application. By accelerating wound healing, dipyridamole with papaverine probably stimulate the division of stem cells at the periphery without enhancing bone marrow function.

pharmacology and toxicology↗

bioRxiv2016

Immunotropic aspect of the Bacillus coagulans probiotic action

Immunotropic aspect of the Bacillus coagulans probiotic action\n\nObjectiveCurrently, probiotics are increasingly used as the alternative to antibiotics as well as the preventive measures in humans. In particular, probiotics occupy a key position in the treatment of antibiotics-associated intestinal dysbiosis. A spore-forming microorganism lactobacillus Bacillus coagulans is one of the most promising probiotics. However, some of its pharmacological effects remain poorly understood.\n\nAim.This study is aimed at investigation of the effect of Bacillus coagulans (Laktovit Forte) on the intestinal dysbiosis syndrome in mice caused by streptomycin against the background of cyclophosphamide-induced cellular immunodeficiency.\n\nMethods.Pharmacological method: mouse model in vivo with immunodeficiency caused by cyclophosphamide.\n\nKey findings.In mice with colitis caused by streptomycin treatment, the administration of Bacillus coagulans (Laktovit Forte medicinal product) resulted in an antidiarrheal effect, normalization of gastrointestinal motility, and prevention of the animals weight loss. Given the cyclophosphamide-induced immunosuppression and streptomycin-associated diarrhoea, the immunity was completely restored only under the action of Bacillus coagulans.\n\nConclusions.According to all parameters, Bacillus coagulans has been proved to be more effective as compared to the Linex Forte reference product containing lacto- and bifidobacteria.

pharmacology and toxicology↗