Biology subjects

Marques-Vidal, P.

Publications and source records attributed to Marques-Vidal, P..

4 recordsLinked to original sources

bioRxiv2024

Associations between common genetic variants and income provide insights about the socioeconomic health gradient

We conducted a genome-wide association study (GWAS) on income among individuals of European descent and leveraged the results to investigate the socio-economic health gradient (N=668,288). We found 162 genomic loci associated with a common genetic factor underlying various income measures, all with small effect sizes. Our GWAS-derived polygenic index captures 1 - 4% of income variance, with only one-fourth attributed to direct genetic effects. A phenome-wide association study using this polygenic index showed reduced risks for a broad spectrum of diseases, including hypertension, obesity, type 2 diabetes, coronary atherosclerosis, depression, asthma, and back pain. The income factor showed a substantial genetic correlation (0.92, s.e. = .006) with educational attainment (EA). Accounting for EAs genetic overlap with income revealed that the remaining genetic signal for higher income related to better mental health but reduced physical health benefits and increased participation in risky behaviours such as drinking and smoking.

genetics↗

bioRxiv2019

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To provide new insights in the biology of sleep-associated adverse lipid profile, we conducted multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identified 49 novel lipid loci, and 10 additional novel lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identified new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The novel gene-sleep interactions had a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explained 4.25% of the variance in triglyceride concentration. Collectively, these findings contribute to our understanding of the biological mechanisms involved in sleep-associated adverse lipid profiles.

genomics↗

bioRxiv2018

Detecting overlapping spatial clusters of high sugar-sweetened beverage intake and high body mass index in a general population: a cross-sectional study

ObjectiveTo identify populations and areas presenting higher consumption of sugar-sweetened beverages (SSB) and their overlap with populations and areas presenting higher body mass index (BMI).\n\nDesignCross-sectional population-based study.\n\nSettingState of Geneva, Switzerland.\n\nParticipants15,767 non-institutionalized residents aged between 35 and 74 years (20 and 74 since 2011) of the state of Geneva, Switzerland.\n\nMain outcome measuresSpatial indices of sugar-sweetened beverage intake frequency and body mass index. Median regression analysis was used to control for characteristics of patients.\n\nResultsThe SSB intake frequency and the BMI were not randomly distributed across the state. Among the 15,423 participants retained for the analyses, 2,034 (13.2%) were within clusters of high SSB intake frequency and 1,651 (10.7%) was within clusters of low SSB intake frequency, 11,738 (76.1%) showed no spatial dependence. We also identified clusters of BMI, 4,014 (26.0%) participants were within clusters of high BMI and 3,591 (23.3%) were within clusters of low BMI, 7,818 (50.7%) showed no spatial dependence. We found that clusters of SSB intake frequency and BMI overlap in specific areas. 1,719 (11.1%) participants were within high SSB intake frequency and high BMI clusters. After adjustment for covariates (education level, gender, age, nationality, and the median income of the area), the identified clusters persisted and were only slightly attenuated.\n\nConclusionA fine-scale spatial approach allows identifying specific populations and areas presenting higher SSB consumption and, for some areas, higher SSB consumption associated with higher BMI. These findings could guide legislators to develop targeted interventions such as prevention campaigns and pave the way for precision public health.\n\nWhat is already known on this topicO_LIThe consumption of sugar-sweetened beverages (SSBs) is an important contributory factor of obesity and obesity-related diseases.\nC_LIO_LISSB consumption varies according to socioeconomic status, which could explain the higher prevalence of obesity in specific areas.\nC_LIO_LISSB taxation faces resistance in many countries due to its potential regressive nature.\nC_LI\n\nWhat this study addsO_LIThe spatial analysis of individual-level SSB consumption in the state of Geneva provides a clear identification of populations and areas presenting higher SSB consumption and, for some areas, higher SSB consumption along with higher body mass index (BMI).\nC_LIO_LIThe results demonstrate the persistence of SSB clustering in the geographic space after adjusting for education level, gender, nationality, age, and neighborhood-level median income.\nC_LIO_LIThe findings provide guidance for future public health interventions to reduce SSB consumption by better targeting vulnerable populations.\nC_LI

epidemiology↗

bioRxiv2018

Genetic studies of accelerometer-based sleep measures in 85,670 individuals yield new insights into human sleep behaviour

Sleep is an essential human function but its regulation is poorly understood. Identifying genetic variants associated with quality, quantity and timing of sleep will provide biological insights into the regulation of sleep and potential links with disease. Using accelerometer data from 85,670 individuals in the UK Biobank, we performed a genome-wide association study of 8 accelerometer-derived sleep traits, 5 of which are not accessible through self-report alone. We identified 47 genetic associations across the sleep traits (P<5x10-8) and replicated our findings in 5,819 individuals from 3 independent studies. These included 26 novel associations for sleep quality and 10 for nocturnal sleep duration. The majority of newly identified variants were associated with a single sleep trait, except for variants previously associated with restless legs syndrome that were associated with multiple sleep traits. Of the new associated and replicated sleep duration loci, we were able to fine-map a missense variant (p.Tyr727Cys) in PDE11A, a dual-specificity 3,5-cyclic nucleotide phosphodiesterase expressed in the hippocampus, as the likely causal variant. As a group, sleep quality loci were enriched for serotonin processing genes and all sleep traits were enriched for cerebellar-expressed genes. These findings provide new biological insights into sleep characteristics.

genetics↗