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Mansencal, B.

Publications and source records attributed to Mansencal, B..

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The link between gender inequality and the distribution of brain regions' relative sizes across the lifespan and the world

Evidence is emerging that the socioeconomic environment in general, and gender inequality in particular, can be a shaping force on brain structure. However, our understanding of the nature of this influence throughout the lifespan is often limited because most current data sets are geographically and demographically narrow, making it unclear whether results hold across distinct world populations. Here we analyse, for the first time, data from an online MRI analysis platform comprising 13277 subjects from 52 countries and the five continents, across ages that range from childhood to late life. We examined how gender inequality, jointly examined with economic inequality, relates to differences in brain grey matter between males and females. We found that the association between female-male brain differences and gender inequality increases with age, suggesting a cumulative effect of gender inequality throughout life. Further, by considering additional variables that are specifically related to the economy, we found that this effect was, as per current data, dominated by the economic aspects of inequality.

neuroscience↗

Lifespan Neurodegeneration Of The Human Brain In Multiple Sclerosis

BackgroundAtrophy related to Multiple Sclerosis (MS) has been found at the early stages of the disease. However, the archetype dynamic trajectories of the neurodegenerative process, even prior to clinical diagnosis, remain unknown. MethodsWe modeled the volumetric trajectories of brain structures across the entire lifespan using 40944 subjects (38295 healthy controls and 2649 MS patients). Then, we estimated the chronological progression of MS by assessing the divergence of lifespan trajectories between normal brain charts and MS brain charts. ResultsChronologically, the first affected structure was the thalamus, then the putamen and the pallidum (3 years later), followed by the ventral diencephalon (7 years after thalamus) and finally the brainstem (9 years after thalamus). To a lesser extent, the anterior cingulate gyrus, insular cortex, occipital pole, caudate and hippocampus were impacted. Finally, the precuneus and accumbens nuclei exhibited a limited atrophy pattern. ConclusionSubcortical atrophy was more pronounced than cortical atrophy. The thalamus was the most impacted structure with a very early divergence in life. It paves the way toward utilization of these lifespan models for future preclinical/prodromal prognosis and monitoring of MS.

neuroscience↗