Biology subjects

Loh, K. K.

Publications and source records attributed to Loh, K. K..

2 recordsLinked to original sources

bioRxiv2020

A collaborative resource platform for non-human primate neuroimaging

Neuroimaging non-human primates (NHPs) is a growing, yet highly specialized field of neuroscience. Resources that were primarily developed for human neuroimaging often need to be significantly adapted for use with NHPs or other animals, which has led to an abundance of custom, in-house solutions. In recent years, the global NHP neuroimaging community has made significant efforts to transform the field towards more open and collaborative practices. Here we present the PRIMatE Resource Exchange (PRIME-RE), a new collaborative online platform for NHP neuroimaging. PRIME-RE is a dynamic community-driven hub for the exchange of practical knowledge, specialized analytical tools, and open data repositories, specifically related to NHP neuroimaging. PRIME-RE caters to both researchers and developers who are either new to the field, looking to stay abreast of the latest developments, or seeking to collaboratively advance the field.

neuroscience↗

bioRxiv2019

Cognitive control of orofacial and vocal responses in the human frontal cortex

The frontal cortical areas critical for human speech production, i.e. the ventrolateral frontal cortex (cytoarchitectonic areas 44 and 45; VLF) and the dorsomedial frontal cortex (DMF) comprising the mid-cingulate cortex (MCC) and the pre-supplementary motor area (preSMA), exist in non-human primates and are implicated in cognitive vocal control functions. The present functional neuroimaging study seeks to define the basic roles of these VLF-DMF network regions in primate vocal production and how they might have been adapted for human speech. We demonstrate that area 44 and the MCC are respectively involved in the cognitive selection of orofacial, non-speech vocal and verbal responses, and the feedback-driven adaptation of these responses - roles that are likely preserved across primates. In contrast, area 45 and preSMA have roles that are specific to human speech: area 45 contributes to active verbal retrieval during learning, while preSMA is involved in processing verbal feedback during orofacial/vocal adaptations.

neuroscience↗