Biology subjects

Lockwood, P. L.

Publications and source records attributed to Lockwood, P. L..

4 recordsLinked to original sources

bioRxiv2026

Tuning in together: LSD enhances inter-brain synchrony and felt connectedness in romantic couples

Social connection is fundamental to human wellbeing. Serotonergic psychedelics such as lysergic acid diethylamide (LSD) acutely heighten subjective connectedness, yet their effects on real-time social connection remain poorly understood. Using EEG hyperscanning in a randomized, double-blind, placebo-controlled crossover study, we recorded neural activity simultaneously from both members of healthy romantic couples (N=25) who received LSD (50 g) or placebo together, across resting and interactive states. LSD increased subjective connectedness, including feelings of love, closeness, trust, and being "in sync," while reducing loneliness, compared to placebo. This affiliative shift dissociated from the drugs pharmacokinetic time-course, remaining elevated as subjective intensity and plasma concentration declined. In parallel, LSD increased inter-brain synchrony during shared rest, carried specifically by theta-band amplitude-envelope coupling. Importantly, this effect survived two complementary controls. First, it exceeded coupling between unrelated individuals and second the effects depended on contemporaneous neural alignment rather than shared drug-induced dynamics. Exploratory analyses showed that romantic partners with greater resting synchrony reported greater feelings of connectedness. These findings provide the first evidence that a psychedelic enhances brain-to-brain coupling between people, linking a pharmacologically induced state of felt connection to a measurable signature shared across interacting brains.

neuroscience↗

bioRxiv2025

Neural signatures of harm aversion predict later willingness to exert effort for others rewards

Prosocial behaviours--actions that incur personal costs to benefit others--are central to human social life. Two key domains are moral harm aversion, where individuals forgo personal gains to prevent harming others, and prosocial effort, which involves exerting effort to benefit others. Although previous studies suggest a relationship between these behaviours, it remains unclear whether neural responses in one domain can predict prosocial motivation in another. Here, we tested whether neural sensitivity to morally salient information in harm aversion could predict prosocial effort later. Participants completed two tasks: a harm aversion task during fMRI, in which they traded off monetary profit against delivering electric shocks to another person; and, one week later, a prosocial effort task outside the scanner, in which they decided whether rewards for others were worth the required physical effort. We focused on three regions implicated in cost-benefit decision-making and social cognition: the anterior cingulate cortex (ACC), anterior insula (AI), and temporoparietal junction (TPJ). Behaviourally, greater harm aversion was associated with increased prosocial effort. Neurally, AI responses to others harm predicted sensitivity to others rewards in the effort task, consistent with a role in representing others outcomes across positive and negative valences. By contrast, TPJ responses to profit from harming others predicted decreased sensitivity to others rewards, suggesting a role in context-dependent valuation that may constrain prosocial behaviour. These findings demonstrate that neural responses to morally salient information in one context correlate with prosocial motivation in another, highlighting mechanisms that bridge moral sensitivity and effortful prosociality.

neuroscience↗

bioRxiv2022

Action initiation and punishment learning differ from childhood to adolescence while reward learning remains stable

Theoretical and empirical accounts suggest that adolescence is associated with heightened reward learning and impulsivity. Experimental tasks and computational models that can dissociate reward learning from the tendency to initiate actions impulsively (action initiation bias) are thus critical to characterise the mechanisms that drive developmental differences. However, existing work has rarely quantified both learning ability and action initiation, or it has tested small samples. Here, using computational modelling of a learning task collected from a large sample (N=742, 9-18 years, 11 countries), we tested differences in reward and punishment learning and action initiation from childhood to adolescence. Computational modelling revealed that whilst punishment learning rates increased with age, reward learning remained stable. In parallel, action initiation biases decreased with age. Results were similar when considering pubertal stage instead of chronological age. We conclude that heightened reward responsivity in adolescence can reflect differences in action initiation rather than enhanced reward learning.

neuroscience↗

bioRxiv2022

Neural representations of vicarious rewards are linked to interoception and prosocial behaviour

Every day we constantly observe other people receiving rewards. Theoretical accounts posit that vicarious reward processing might be linked to peoples sensitivity to internal body states (interoception) and facilitates a tendency to act prosocially. However, the neural processes underlying the links between vicarious reward processing, interoception and prosocial behaviour are poorly understood. Previous research has linked vicarious reward processing to the anterior cingulate gyrus (ACCg) and the anterior insula (AI). Can we predict someones propensity to be prosocial or to be aware of interoceptive signals from variability in how the ACCg and AI process rewards? Here, participants monitored rewards being delivered to themselves or a stranger during functional magnetic resonance imaging. Later, they performed a task measuring their willingness to exert effort to obtain rewards for others, and a task measuring their propensity to be aware and use interoceptive signals. Using multivariate similarity analysis, we show that peoples willingness to be prosocial is predicted by greater similarity between self and other representations in the ACCg. Moreover, greater dissimilarity in self-other representations in the AI is linked to interoceptive propensity. These findings highlight that vicarious reward is linked to bodily signals in AI, and foster prosocial tendencies through the ACCg.

neuroscience↗