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Lienard, J. F.

Publications and source records attributed to Lienard, J. F..

2 recordsLinked to original sources

Intellectual Synthesis in Mentorship Determines Success in Academic Careers

As academic careers become more competitive, junior scientists need to understand the value that mentorship brings to their success in academia. Previous research has found that, unsurprisingly, successful mentors tend to train successful students. But what characteristics of this relationship predict success, and how? We analyzed an open-access database of about 20,000 researchers who have undergone both graduate and postdoctoral training, compiled across several fields of biomedical science. Our results show that postdoctoral mentors were more instrumental to trainees success compared to graduate mentors. A trainees success in academia was predicted by the degree of intellectual synthesis with their mentors, resulting from fusing the influence of disparate advisors. This suggests that junior scientists should have increased chances of success by training with and linking the ideas of mentors from different fields. We discuss the implications of these results for choosing mentors and determining the duration of postdoctoral training.

scientific communication and education

Beta-Band Oscillations without Pathways: the opposing Roles of D2 and D5 Receptors

The timescales of the dynamics of a system depend on the combination of the timescales of its components and of its transmission delays. Parkinsons disease is characterized by the death of dopaminergic neurons and the emergence of strong {beta}-band (15-35Hz) oscillations throughout the basal ganglia nuclei. Here we combine experimental stimulation data from ten studies, that reveal the timing of excitatory and inhibitory events in the basal ganglia circuit, to estimate its set of transmission delays. In doing so, we reveal possible inconsistencies in the existing data, calling for replications, and we propose two possible sets of transmission delays. We then integrate these delays in a model of the primate basal ganglia, that does not rely on direct and indirect pathways segregation, and show that, while much attention has been given to the role of the striatal dopaminergic receptors in Parkinsons disease symptoms, extrastriatal dopaminergic depletion in the external part of the globus pallidus and in the subthalamic nucleus is sufficient to generate {beta}-band oscillations in the high part of the band. More specifically, we show that that D2 and D5 dopamine receptors in these nuclei play opposing roles in the emergence of {beta}-band oscillations, thereby explaining how completely deactivating D5 receptors in the subthalamic nucleus can, paradoxically, cancel oscillations.

neuroscience