Biology subjects

Le Corre, M.

Publications and source records attributed to Le Corre, M..

5 recordsLinked to original sources

bioRxiv2026

Brown and Lesser noddies as epidemiological reservoirs and sentinels of avian influenza virus in the South-western Indian Ocean

Avian influenza virus (AIV) epidemiology is well-documented in temperate regions but remains poorly understood in isolated ecosystems like tropical oceanic islands. On these islands, seabirds nest in dense interspecific colonies where the role of different species as reservoirs and dispersers of AIV may vary greatly. Here, we examine the role of noddies (Anous spp.) as potential reservoirs for low pathogenic AIV and evaluate their potential as sentinel species for highly pathogenic AIV introduction on tropical oceanic islands. We analyzed blood samples from 11 seabird species across eight islands in the southwestern Indian Ocean (2015-2020). Noddies exhibited high, stable seroprevalence (30-45%), comparable to reservoir host species in temperate regions. The detection of two N7-positive noddies, sampled the same year on two distinct islands, provided direct molecular evidence that AIV actively circulates on these island colonies. While most other species showed low exposure, Bridled Terns (Onychoprion anaethetus) had exceptionally high seroprevalence (80%), though their reservoir status requires further investigation due to limited sampling. Given noddies consistent exposure and regional distribution, we recommend prioritizing islands with large noddy populations for AIV surveillance. Continued investigation of viral dynamics within and among islands is now called for to elucidate the ecological drivers of AIV maintenance and transmission.

ecology↗

bioRxiv2025

Megafauna show pervasive yet distinct affinity to ocean fronts: the urgent need for adaptive conservation in a warming world

Fronts are ephemeral structures in the ocean that mark the boundaries between water masses of different properties, attracting a wide range of marine organisms, from plankton to whales. Despite their fundamental role in marine ecosystem functioning, the association with biodiversity has mainly focused on single species in regions with high data availability. Here, using multidecadal datasets on dynamical and thermal fronts, satellite tracking, and aerial observations, we assess marine megafauna associations with ocean fronts in the ecologically rich yet highly turbulent Mozambique Channel. We find that a diverse array of species associate with various ocean fronts, although the strength and type of affinity vary across taxa. Downscaled climate change simulations predict significant spatial shifts in front-rich areas by the end of the century. As climate change reshapes ocean front dynamics, adaptive management strategies will be essential to balance conservation and resource use in these critical ecosystems. TeaserOcean fronts attract marine megafauna, but climate change might alter these habitats, requiring adaptive conservation strategies.

ecology↗

bioRxiv2023

Absence of Coronavirus in terns in the Western Indian Ocean?

We investigated coronavirus circulation in three tern species, in four islands of the Western Indian Ocean (Bird, Reunion, Europa, Juan de Nova). None of the 1513 samples tested positive by RT-PCR. We discuss the implication in term of host species range, ecological drivers of virus transmission, and diagnostic tools.

ecology↗

bioRxiv2023

Migratory patterns of two major influenza virus host species on tropical islands

Animal migration is a major driver of infectious agent dispersal. Duck and seabirds migrations, for instance, play a key role in the spatial transmission dynamics and gene flows of avian influenza viruses (AIV), worldwide. On tropical islands, brown and lesser noddies (Anous stolidus and A. tenuirostris) may be important AIV hosts, but the lack of knowledge on their migratory behaviour limits our understanding of virus circulation in island networks. Here we show that high connectivity between islands generated by post-breeding behaviours could be a major driver in the spread and the maintenance of AIV among tropical islands. Tracking data highlight two types of behaviours during the non-breeding season: birds either staying in the vicinity of their breeding ground (on Bird Island, Seychelles), or moving to and roosting on other islands in the Indian Ocean. Differences in roosting places are detected between migrant birds, ranging from the Tanzanian coast to the Maldives archipelago and Tromelin Island. Epidemiological data further support that brown and lesser noddies are major hosts for AIV, although significant variation of seroprevalence between species suggest that other drivers are involved in virus infection and transmission dynamics.

ecology↗

bioRxiv2019

In Vivo Large Scale Mapping Of Protein Turnover In The Human Cerebrospinal Fluid

The extraction of accurate physiological parameters from clinical samples provides a unique perspective to understand disease etiology and evolution, including under therapy. We introduce a new proteomics framework to map patient proteome dynamics in vivo, either proteome wide or in large targeted panels. We applied it to ventricular cerebrospinal fluid (CSF) and could determine the turnover parameters of almost 200 proteins, whereas a handful were known previously. We covered a large number of neuron biology- and immune system-related proteins including many biomarkers and drug targets. This first large data set unraveled a significant relationship between turnover and protein origin that relates to our ability to investigate the central nervous system physiology precisely in future studies. Our data constitute a reference in CSF biology as well as a repertoire of peptides for the community to design new proteome dynamics analyses. The disclosed methods apply to other fluids or tissues provided sequential sample collection can be performed.

systems biology↗