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Larmande, P.

Publications and source records attributed to Larmande, P..

7 recordsLinked to original sources

GRU-SCANET: Unleashing the Power of GRU-based Sinusoidal CApture Network for Precision-driven Named Entity Recognition

MotivationPre-trained Language Models (PLMs) have achieved remarkable performance across various natural language processing tasks. However, they encounter challenges in biomedical Named Entity Recognition (NER), such as high computational costs and the need for complex fine-tuning. These limitations hinder the efficient recognition of biological entities, especially within specialized corpora. To address these issues, we introduce GRU-SCANET (Gated Recurrent Unit-based Sinusoidal Capture Network), a novel architecture that directly models the relationship between input tokens and entity classes. Our approach offers a computationally efficient alternative for extracting biological entities by capturing contextual dependencies within biomedical texts. ResultsGRU-SCANET combines positional encoding, bidirectional GRUs (BiGRUs), an attention-based encoder, and a conditional random field (CRF) decoder to achieve high precision in entity labeling. This design effectively mitigates the challenges posed by unbalanced data across multiple corpora. Our model consistently outperforms leading benchmarks, achieving better performance than BioBERT (8/8 evaluations), PubMedBERT (5/5 evaluations), and the previous state-of-the-art (SOTA) models (8/8 evaluations), including Bern2 (5/5 evaluations). These results highlight the strength of our approach in capturing token-entity relationships more effectively than existing methods, advancing the state of biomedical NER.

bioinformatics↗

PyRice: a Python package for querying Oryza Sativa functional databases

SummaryCurrently, gene information available for Oryza sativa species is located in various online heterogeneous data sources. Moreover, methods of access are also diverse, mostly web-based and sometimes query APIs, which might not always be straightforward for domain experts. The challenge is to collect information quickly from these applications and combine it logically, to facilitate scientific research. We developed a Python package named PyRice, a unified programming API to access all supported databases at the same time with consistent output. PyRice design is modular and implements a smart query system which fits the computing resources to optimize the query speed. As a result, PyRice is easy to use and produces intuitive results. Availability and implementationhttps://github.com/SouthGreenPlatform/PyRice Documentationhttps://pyrice.readthedocs.io Contactpierre.larmande@ird.fr Licence informationMIT Supplementary informationSupplementary data are available online.

bioinformatics↗

Enabling Fast Annotation Process With Table2Annotation Tool

Semantic annotation is the process in which semantic concepts are linked to natural language. It helps in boosting the search and access of resources and can be used in information retrieval systems to increase the queries from the user. In this paper, we are interested in identifying ontological concepts in scientific text contained in spreadsheet. We developed a tool which is able to handle various types of spreadsheet. Furthermore, we used the benefits of NCBO Annotator API provided by BioPortal to enhance the semantic annotation functionalities covering spreadsheet data. Table2Annotation developed strengths in certain criteria like speed, error handling and complex concept matching. AvailabilityGitHub : https://github.com/pierrelarmande/ontology-project

bioinformatics↗

Benchmarking Database Systems for Genomic Selection Implementation

MotivationWith high-throughput genotyping systems now available, it has become feasible to fully integration genotyping information into breeding programs [22]. To make use of this information effectively requires DNA extraction facilities and marker production facilities that can efficiently deploy the desired set of markers across samples with a rapid turnaround time that allows for selection before crosses needed to be made. In reality, breeders often have a short window of time to make decisions by the time they are able collect all their phenotyping data and receive corresponding genotyping data. This presents a challenge to organize information and utilize them in downstream analyses to support decisions made by breeders. In order to implement genomic selection routinely as part of breeding programs one would need an efficient genotype data storage system. We selected and benchmarked six popular open-source data storage systems, including relational database management and columnar storage systems.\n\nResultsWe found that data extract times are greatly influenced by the orientation in which genotype data is stored in a system. HDF5 consistently performed best, in part because it can more efficiently work with both orientations of the allele matrix.\n\nAvailabilityhttp://gobiinx1.bti.cornell.edu:6083/projects/GBM/repos/benchmarking/browse\n\nContactyn259@cornell.edu

genomics↗

Evaluating Named-Entity Recognition approaches in plant molecular biology

Text mining research is becoming an important topic in biology with the aim to extract biological entities from scientific papers in order to extend the biological knowledge. However, few thorough studies on text mining and applications are developed for plant molecular biology data, especially rice, thus resulting a lack of datasets available to train models able to detect entities such as genes, proteins and phenotypic traits. Since there is rare benchmarks for rice, we have to face various difficulties in exploiting advanced machine learning methods for accurate analysis of rice bibliography. In this article, we developed a new training datasets (Oryzabase) as the benchmark. Then, we evaluated the performance of several current approaches to find a methodology with the best results and assigned it as the state of the art method for our own technique in the future. We applied Name Entities Recognition (NER) tagger, which is built from a Long Short Term Memory (LSTM) model, and combined with Conditional Random Fields (CRFs) to extract information of rice genes and proteins. We analyzed the performance of LSTM-CRF when applying to the Oryzabase dataset and improved the results up to 86% in F1. We found that on average, the result from LSTM-CRF is more exploitable with the new benchmark.

bioinformatics↗

Rice Galaxy: an open resource for plant science

Background\n\nRice molecular genetics, breeding, genetic diversity, and allied research (such as rice-pathogen interaction) have adopted sequencing technologies and high density genotyping platforms for genome variation analysis and gene discovery. Germplasm collections representing rice diversity, improved varieties and elite breeding materials are accessible through rice gene banks for use in research and breeding, with many having genome sequences and high density genotype data available. Combining phenotypic and genotypic information on these accessions enables genome-wide association analysis, which is driving quantitative trait loci (QTL) discovery and molecular marker development. Comparative sequence analyses across QTL regions facilitate the discovery of novel alleles. Analyses involving DNA sequences and large genotyping matrices for thousands of samples, however, pose a challenge to non-computer savvy rice researchers.\n\nFindings\n\nWe adopted the Galaxy framework to build the federated Rice Galaxy resource, with shared datasets, tools, and analysis workflows relevant to rice research. The shared datasets include high density genotypes from the 3,000 Rice Genomes project and sequences with corresponding annotations from nine published rice genomes. Rice Galaxy includes tools for designing single nucleotide polymorphism (SNP) assays, analyzing genome-wide association studies, population diversity, rice-bacterial pathogen diagnostics, and a suite of published genomic prediction methods. A prototype Rice Galaxy compliant to Open Access, Open Data, and Findable, Accessible, Interoperable, and Reproducible principles is also presented.\n\nConclusions\n\nRice Galaxy is a freely available resource that empowers the plant research community to perform state-of-the-art analyses and utilize publicly available big datasets for both fundamental and applied science.

bioinformatics↗

Agronomic Linked Data (AgroLD): a Knowledge-based System to Enable Integrative Biology in Agronomy

Recent advances in high-throughput technologies have resulted in a tremendous increase in the amount of omics data produced in plant science. This increase, in conjunction with the heterogeneity and variability of the data, presents a major challenge to adopt an integrative research approach. We are facing an urgent need to effectively integrate and assimilate complementary datasets to understand the biological system as a whole. The Semantic Web offers technologies for the integration of heterogeneous data and their transformation into explicit knowledge thanks to ontologies. We have developed the Agronomic Linked Data (AgroLD - www.agrold.org), a knowledge-based system relying on Semantic Web technologies and exploiting standard domain ontologies, to integrate data about plant species of high interest for the plant science community e.g., rice, wheat, arabidopsis. We present some integration results of the project, which initially focused on genomics, proteomics and phenomics. AgroLD is now an RDF (Resource Description Format) knowledge base of 100M triples created by annotating and integrating more than 50 datasets coming from 10 data sources -such as Gramene.org and TropGeneDB- with 10 ontologies -such as the Gene Ontology and Plant Trait Ontology. Our evaluation results show users appreciate the multiple query modes which support different use cases. AgroLDs objective is to offer a domain specific knowledge platform to solve complex biological and agronomical questions related to the implication of genes/proteins in, for instances, plant disease resistance or high yield traits. We expect the resolution of these questions to facilitate the formulation of new scientific hypotheses to be validated with a knowledge-oriented approach.

bioinformatics↗