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Kwati, L.

Publications and source records attributed to Kwati, L..

2 recordsLinked to original sources
bioRxiv2024

Green synthesis, characterization, and potential antimicrobial studies of Ag-MgO nanocomposites mediated from Talinum triangulare leaf extract

In this study, Ag-MgONCs (silver-magnesium oxide nanocomposites) were fabricated using Talinum triangulare leaf extract as a renewable, mild reducing, and stabilizing agent. The synthesis process involved molecular interactions between pre-prepared AgNPs (silver nanoparticles) and in situ-prepared MgO. Confirmation of the nanocomposites came from micrographic images obtained through SEM-EDX analysis. Dynamic light scattering (DLS) revealed a characteristic nanocomposite size of 295 nm. The infrared spectrum (FTIR) proved interactions between T. triangulare and Ag. Additionally, X-ray patterns of AgNPs and Ag-MgONCs confirmed hexagonal and cubic crystalline states, respectively, with average particle sizes of 17 nm. Furthermore, an in vitro analysis against five bacterial strains (Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Proteus mirabilis) revealed pronounced activity of the nanocomposites, particularly against Proteus mirabilis, indicating bactericidal potential.

pharmacology and toxicology↗
bioRxiv2024

Phytoassisted synthesis of biogenic silver nanoparticles using Vernonia amygdalina leaf extract: characterization, antibacterial, anti-inflammatory, and acute toxicity profile

Increasing antimicrobial resistance and pathological consequences from long-term anti-inflammatory drug use necessitate the urgent discovery and rational design of new, effective antimicrobial and anti-inflammatory agents. This study reports the antibacterial, anti-inflammatory, and acute toxicity profile of Vernonia amygdalina leaf extract-mediated silver nanoparticles (VA-AgNPs). VA-AgNPs were synthesized by mixing Ag+ ions with an aqueous leaf extract from Vernonia amygdalina and characterized using UV-Visible (UV-Vis) spectroscopy, powder X-ray diffraction (PXRD), and scanning electron microscopy (SEM). Antibacterial activity against Escherichia coli strains, carrageenan-induced rat paw edema, and oral acute toxicity assays were performed. The change in color from light brown to dark brown indicated the formation of VA-AgNPs, which was further confirmed by the surface plasmon resonance peaks between 400 and 450 nm in the UV-Vis spectrum. Stability studies showed increased VA-AgNPs formation at basic pH and with higher reactant quantities. The X-ray pattern showed nanocrystalline particles of Ag and AgCl with mean sizes of 13 and 18 nm, respectively. The SEM images depict aggregates of spherical shapes. The synthesized VA-AgNPs inhibited Escherichia coli growth with a minimum inhibition concentration of 0.125 mg/mL and rat paw edema with a maximum inhibition percentage of 96% at a dose of 0.4 mg/kg body weight. Oral administration of VA-AgNPs was not associated with any toxicity, supporting their use in the development of new effective antibacterial and anti-inflammatory drugs.

pharmacology and toxicology↗