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Kunduzova, O.

Publications and source records attributed to Kunduzova, O..

2 recordsLinked to original sources

GTEM cell design for controlled exposure to electromagnetic fields in biological system

This study describes a structure design of the Gigaherz Transverse Electromagnetic (GTEM) cell for electromagnetic tests in biological systems. Using electromagnetic simulation software we show that the optimization of final structure assures the criteria imposed on a low level of reflection towards the radio frequency generator, and a fairly uniform field in the test zone. A sensitivity study was also conducted when the cell was loaded with a few samples under test. We report that the level of reflection remains adequate as long as the test volume remains limited in relation to the size of the cell. The first estimation results on the SAR values are consistent with the distribution of the fields in the cell. A cell was fabricated with the design data, and tested for the reflection level. The measurements confirm the results of simulations.

biophysics↗

Fibrosis protein-protein interactions from Google matrix analysis of MetaCore network

Protein-protein interactions is a longstanding challenge in cardiac remodeling processes and heart failure. Here we use the MetaCore network and the Google matrix algorithms for prediction of protein-protein interactions dictating cardiac fibrosis, a primary causes of end-stage heart failure. The developed algorithms allow to identify interactions between key proteins and predict new actors orchestrating fibroblast activation linked to fibrosis in mouse and human tissues. These data hold great promise for uncovering new therapeutic targets to limit myocardial fibrosis.

systems biology↗