Biology subjects

Kolezeva, Y.

Publications and source records attributed to Kolezeva, Y..

3 recordsLinked to original sources

bioRxiv2018

The identification of cortical pyramidal neurons using a RPP based algorithm

Appropriately classifying neuronal subgroups is critical to numerous downstream procedures in several disciplines of biomedical research. The cortical pyramidal neuron characterization technology has achieved rapid development in recent years. However, capturing true neuronal features for accurate pyramidal neuron characterization and segmentation has remained elusive. In the current study, a novel global preserving estimate algorithm is used to capture the non-linearity in the features of cortical pyramidal neuron after Factor Algorithm. Our results provide evidence for the effective integration of the original linear and nonlinear neuronal features and achieves better characterization performance on multiple cortical pyramidal neuron databases through array matching.

neuroscience↗

bioRxiv2018

Changes In The Axon Initiation Segment Of Thalamic Neurons In Response To Cyclical Stimulation

Changes to the axon initiation segment in frequently firing neurons are known to be important predictors of early disease states. Studying this phenomenon in thalamic neurons is critical to understanding the first insult implicated in multiple neuro-degenerative disorders. To study these changes we used cyclical stimulations using micro-electrodes to the axon initiation segment of mouse thalamic neurons. Numerical simulation results indicate that axon initiation segment water potential fluctuated sinusoidally on high voltage only. Fluctuations in the amplitude and trend were caused by calcium flow and storage resistance, respectively. The change in axon initiation segment-stored water was proportional to the change rate in water potential. Axon initiation segment diameter increased with fluctuations in calcium free media; moreover, it varied slightly under low voltage conditions. Our results indicate that the changes in axon initiation segment diameter were caused by changes in water potential, which can be attributed to subcellular gated calcium channels within the thalamic neurons.

neuroscience↗

bioRxiv2017

Factor analysis on the Tasmanian topsoil microscopic community

To help with stand restoration, the influence of width size on the Tasmanian topsoil microscopic community was studied in an Athrotaxis cupressoides stand suffering from hail storm damage. The functional diversity of topsoil microbial groups was estimated from degradation of 31 substrates on Bencho EcoPlates. Using Factor Analysis (FA) we found width size had a significant influence on average column colorimetric disseminator analysis (AVGCLR) and on the Rao indices of topsoil microbial diversity. Compared with large widths, small widths had higher AVGCLR. The ten widths were divided into three groups by cluster analysis and FA: group 1 reflected large widths, while groups 2 and 3 reflected small widths. Thirty-one sole carbon sources were divided into three groups by FA. Using an eigenvector greater than 0.5 as a standard for checking carbon (C) sources, nineteen kinds of C sources included in principal components 1 and 2 had a relatively high influence on the topsoil microbial community, including carbohydrates, amino acids and carboxylic acids. This indicates that the use by topsoil microorganisms of carboxylic acids, sugars and amino acids was greater than other C sources. These findings suggest that width size played a key role in the topsoil microbial diversity after a natural disturbance.

ecology↗