Biology subjects

Kinney, M.

Publications and source records attributed to Kinney, M..

4 recordsLinked to original sources

bioRxiv2025

Species interactions, divergence, and the rapid evolution of ecological sexual dimorphism in threespine sticklebacks

Variation in ecological sexual dimorphism (ESD), defined as differences between the sexes in ecologically-relevant traits, is a common feature of adaptive radiation, yet its causes remain unclear. Competition between the sexes for alternative resources can promote evolution of ESD when interspecific competition is reduced (competition hypothesis). Alternatively, sex-specific selection on ecological traits might weaken under strong directional selection in new environments (divergence hypothesis). We tested these hypotheses via their expected evolutionary outcomes in threespine stickleback populations from southwestern Canada. We found striking among-population variation in magnitude of ESD. Consistent with the divergence hypothesis, dimorphism along the main axis of body shape variation was reduced in recently derived freshwater populations compared to their contemporary marine ancestor. However, dimorphism only weakly declined with increasing phenotypic divergence. Average dimorphism along major freshwater body shape axes was similar between solitary populations and those coexisting with a competing species, contrary to the competition hypothesis. Instead, sympatry with a Benthic ecotype led to increased sexual size dimorphism in Limnetics, and total shape dimorphism was elevated in the sympatric stickleback species compared with solitary populations. In contrast to the mechanisms considered in existing theory, interactions in sympatry might produce elevated ESD by generating novel sex-specific selection pressures.

evolutionary biology↗

bioRxiv2024

A proposed framework for evaluating meat alternatives

Concerns surrounding the environmental, economic, and ethical consequences of meat production and industrial agriculture have prompted substantial research and capital investment into the production of meat alternatives. Alternative meat production encompasses a variety of technological approaches including plant-based meats, cell-based or cultivated meats, meat alternatives relying on fungal protein sources, and hybrids thereof; each of which offers unique advantages and disadvantages and has been associated with a myriad of claims supporting it as the preferred alternative to animal-derived meats. As part of XPRIZE Foundations Feed the Next Billion competition, we developed a framework for evaluating meat alternatives by measuring their structural, nutritional, and organoleptic properties while also assessing safety and their purported environmental and economic benefits compared to animal-derived meats. The framework is technologically agnostic and can be used to evaluate meat alternatives of all types. The output of the framework enables a data-driven comparison to animal-derived meat and/or other alternative meats, allowing a range of stakeholders (e.g., food startups, investors, government) to assess technological readiness, competitive advantage, and impact potential. This framework can assist this nascent industry as it moves towards standardizing approaches to evaluating the quality, safety and proposed benefits of meat alternatives.

bioengineering↗

bioRxiv2023

Accounting for population growth, intermittent breeding, and aging error in close-kin mark-recapture assessments

Obtaining robust estimates of population abundance is a central challenge hindering the conservation and management of many threatened and exploited species. Close-kin mark-recapture (CKMR) is a genetics-based approach that has strong potential to improve monitoring of data-limited species by enabling estimates of abundance, survival, and other parameters for populations that are challenging to assess. However, CKMR models have received limited sensitivity testing under realistic population dynamics and sampling scenarios, impeding application of the method in population monitoring programs and stock assessments. Here, we use individual-based simulation to examine how unmodeled population dynamics and aging uncertainty affect the accuracy and precision of CKMR parameter estimates under different sampling strategies. We then present adapted models that correct the biases that arise from model misspecification. Our results demonstrate that a simple base-case CKMR model produces robust estimates of population abundance with stable populations that breed annually; however, if a population trend or non-annual breeding dynamics are present, or if year-specific estimates of abundance are desired, a more complex CKMR model must be constructed. In addition, we show that CKMR can generate reliable abundance estimates for adults from a variety of sampling strategies, including juvenile-focused sampling where adults are never directly observed (and aging error is minimal). Finally, we apply a CKMR model that has been adapted for population growth and intermittent breeding to two decades of genetic data from juvenile lemon sharks (Negaprion brevirostris) in Bimini, Bahamas, to demonstrate how application of CKMR to samples drawn solely from juveniles can contribute to monitoring efforts for highly mobile populations. Overall, this study expands our understanding of the biological factors and sampling decisions that cause bias in CKMR models, identifies key areas for future inquiry, and provides recommendations that can aid biologists in planning and implementing an effective CKMR study, particularly for long-lived data-limited species.

ecology↗

bioRxiv2022

Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-PRC1 axis

Hematopoiesis changes over life to meet the demands of maturation and aging. Here, we find that the definitive hematopoietic stem and progenitor cell (HSPC) compartment is remodeled from gestation into adulthood, a process regulated by the heterochronic Lin28b/let-7 axis. Native fetal and neonatal HSPCs distribute with a pro-lymphoid/erythroid bias with a shift toward myeloid output in adulthood. By mining transcriptomic data comparing juvenile and adult HSPCs and reconstructing coordinately activated gene regulatory networks, we uncover the Polycomb repressor complex 1 (PRC1) component Cbx2 as an effector of Lin28b/let-7s control of hematopoietic maturation. We find that juvenile Cbx2-/- hematopoietic tissues show impairment of B-lymphopoiesis and a precocious adult-like myeloid bias and that Cbx2/PRC1 regulates developmental timing of expression of key hematopoietic transcription factors. These findings define a novel mechanism of epigenetic regulation of HSPC output as a function of age with potential impact on age-biased pediatric and adult blood disorders.

developmental biology↗