KM, A. | bioRxiv Science

bioRxiv2025

Aging-Driven Immunosuppression: The Role of Tregs in the Ovarian Tumor Microenvironment

Epithelial ovarian cancer (EOC) incidence and mortality increase with age, driven in part by chronic inflammation, diminished T cell output, and heightened regulatory T cell (Treg)-mediated immunosuppression. In aged EOC-bearing mice, we observed reduced survival, accompanied by impaired CD4 and CD8T cell responses and a marked expansion of FOXP3 Tregs exhibiting elevated IL-10 and TGF{beta} expression. Metabolic profiling revealed enhanced oxidative phosphorylation in Tregs from aged mice, along with a fivefold increase in intracellular succinate levels. This accumulation of succinate within the aged tumor microenvironment was found to potentiate Treg suppressive function. Notably, pharmacologic inhibition of -ketoglutarate dehydrogenase reversed this effect, restoring effector T cell activity. These findings highlight succinate driven metabolic reprogramming as a central mechanism of age related Treg dysfunction in EOC and suggest that targeting succinate metabolism may offer a promising strategy to rejuvenate antitumor immunity in elderly patients.

immunology↗

bioRxiv2024

Craving Connections: Exploring the Relationship Between Pregnancy Cravings, Maternal Health, and Child Preferences in Indian Families

Although Pregnancy cravings are a common phenomenon, their implications on maternal health, family dietary habits, and child food preferences remain underexplored, particularly in the Indian context. This study aimed to investigate the prevalence and nature of pregnancy cravings among Indian women and their potential impact on maternal health outcomes and family dietary patterns. A cross-sectional survey was conducted with 119 women who had experienced pregnancy, collecting data on craving patterns, maternal health indicators, and perceived influences on family diet. Results revealed that most women craved sugary snacks, predominantly in the second trimester. Notably, 61.9% of participants cravings did not align with their spouses food preferences, suggesting potential shifts in family dietary habits. The study also found associations between cravings, mood swings, and morning sickness, highlighting the complex interplay of physiological and psychological factors during pregnancy. These findings underscore the need for culturally sensitive, personalised prenatal care that address both the nutritional and emotional aspects of pregnancy cravings, influencing long-term family health outcomes.

scientific communication and education↗