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K, A.

Publications and source records attributed to K, A..

2 recordsLinked to original sources

Biodiversity clock and conservation triangle: Integrative platform for biodiversity monitoring, evaluation, and preemptive conservation intervention

Business-as-usual is no more an option on the table for biodiversity conservation. Disruptive transformation at both policy and polity levels are pressing needs. The possibilities presented by the current wave of information and communication technology can act as travelators to meet the conservation targets. Here, we introduce twin concepts of biodiversity clock and conservation triangle that posit as convergence plane to seamlessly consolidate ongoing discrete efforts and convey real-time biodiversity information in a lucid schematic form. In its present form, the biodiversity clock depicts 12 ecological and 6 biophysical components. The universal consistency in clock-reading facilitates the biodiversity clock to be read and interpreted identically across the world. A ternary plot of the International Union of Conservation of Nature (IUCN) species conservation status is presented as the conservation triangle. Together, the biodiversity clock and the conservation triangle are invaluable in strategizing biodiversity conservation, post-2020. Leveraged smartly, they make possible pre-emptive intervention for biodiversity conservation.

ecology

Non-coding RNAs control metabolic state in mycobacteria

Non-coding RNAs play pivotal roles in bacterial signaling. However, RNAs from certain phyla (specially high-GC actinobacteria) remain elusive. Here, by revamping existing approaches we discover a family of structurally conserved RNAs in actinobacteria. These RNAs function by the recruiting ANTAR proteins to select transcripts; regulating them via translational repression. By overlapping with ORF start sites, these RNAs provide mechanisms by which even leader-less transcripts are regulated. In mycobacteria, transcripts marked by ANTAR-target RNAs are few but encode important redox enzymes especially involved in lipid metabolism. Notably, the cellular response to ANTAR-regulation is hierarchical, wherein immediate metabolic changes induced by ANTAR-RNA binding are amplified through a global transcriptomic response. This includes several genes from oxidative/reductive pathways; ultimately switching cells towards reductive metabolism. This discovery of ANTAR-target RNAs and associated regulation places RNAs as crucial players in controlling metabolic flexibility of mycobacteria, proposing a prominent role for ANTAR regulation across actinobacteria.

biochemistry