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Jin, C. Y.

Publications and source records attributed to Jin, C. Y..

2 recordsLinked to original sources

Decoding Study-Independent Mind-Wandering from EEG using Convolutional Neural Networks

ObjectiveMind-wandering is a mental phenomenon where the internal thought process disengages from the external environment periodically. In the current study, we trained EEG classifiers using convolutional neural networks (CNN) to track mind-wandering across studies. ApproachWe transformed the input from raw EEG to band-frequency information (power), singletrial ERP (stERP) patterns, and connectivity matrices between channels (based on inter-site phase clustering, ISPC). We trained CNN models for each input type from each EEG channel as the input model for the meta-learner. To verify the generalizability, we used leave-N-participant-out crossvalidations (N=6) and tested the meta-learner on the data from an independent study for across-study predictions. Main resultsThe current results show limited generalizability across participants and tasks. Nevertheless, our meta-learned trained with the stERPs performed the best among the state-of-theart neural networks. The mapping of each input model to the output of the meta-learner indicates the importance of each EEG channel. SignificanceOur study makes the first attempt to train study-independent mind-wandering classifiers. The results indicate that this remains challenging. The current proposed stacking neural network design allows an easy inspection of channel importance and feature maps.

neuroscience↗

Modular HUWE1 architecture serves as hub for degradation of cell-fate decision factors

HECT ubiquitin ligases play essential roles in metazoan development and physiology. The HECT ligase HUWE1 is central to the cellular stress response by mediating degradation of key death or survival factors including Mcl1, p53, DDIT4, and Myc. As a step toward understanding regulation of HUWE1 engagement with its diverse substrates, we present here the cryo-EM structure of HUWE1, offering a first complete molecular picture of a HECT ubiquitin ligase. The ~4400 amino acid residue polypeptide forms an alpha solenoid-shaped assembly with a central pore decorated with protein interaction modules. This modularity enables HUWE1 to target a wide range of substrates for destruction. The locations of human mutations associated with severe neurodevelopmental disorders link functions of this essential enzyme with its three-dimensional organization.

molecular biology↗