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Biology subjects

Jevtovic, F.

Publications and source records attributed to Jevtovic, F..

2 recordsLinked to original sources

Effects of maternal exercise modes on infant cord blood proteome

The aim of this study was to show the effects of different maternal exercise modes on infant cord blood proteome. We used infant cord blood from two randomized controlled trials where women with a wide range of BMI and free of pregnancy complications participated in controlled and supervised aerobic, resistance, or combination (aerobic+resistance) exercise from <16 weeks of gestation until delivery. Results of this study showed that infant cord blood proteome is altered in a maternal exercise mode specific manner. Additionally, results showed 61 downregulated proteins common to all exercise modes, which correspond to gas transport, cellular stress response, reactive oxygen species metabolism, and other biological processes. Collectively, these data demonstrate the differential effect of maternal exercise modes on infant cord blood proteome.

physiology↗

Maternal exercise alters placental proteome in an exercise mode-specific manner

Maternal exercise is a widely recommended and safe intervention associated with the improvement of maternal gestational and infant metabolic health. While various modes of exercise are deemed safe during pregnancy, the effects of supervised maternal aerobic, resistance, and combination (aerobic+resistance) exercise remain understudied. Specifically, it remains unknown how different modes of maternal exercise affect the placenta, an organ central to maternal-fetal communication and successful pregnancy outcomes. This study aimed to characterize the placental proteomic changes in response to controlled and supervised maternal exercise during gestation. Results showed that the placental proteomic landscape changes in an maternal exercise mode-specific way. Additionally, proteomics revealed that [~]20% of the identified placental proteins were associated with maternal exercise volume during gestation. These results highlight the differential effect maternal exercise modes have on the placental proteome and further implicate the placenta in mediating the effects of maternal exercise on maternal and infant health.

developmental biology↗