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Ince, M.

Publications and source records attributed to Ince, M..

2 recordsLinked to original sources

Object features survive motion at saccadic speed but lose their link to specific objects

Saccadic eye movements sweep objects across the retina at high speed, and this motion is routinely omitted from conscious perception. Whether object identity survives such motion is unclear. In two preregistered experiments (N = 20 and N = 19), we asked how object motion at saccadic speeds, while the eyes fixate, affects object continuity in the object-reviewing paradigm (Kahneman et al., 1992; Sasi et al., 2023). Two Gabor patches each carried a digit, then disappeared and reappeared in place, reappeared displaced, or travelled continuously to their new locations; the intervening interval lasted 300 ms or was matched to the mean or peak speed of a saccade. A target digit then appeared in one patch, and participants identified it. At the long duration, we replicated the Object-Specific Preview Benefit (OSPB): responses were faster when the target had been previewed in that same object than in the other one. At saccadic durations, the OSPB disappeared, and adding a distinguishing surface feature in Experiment 2 did not restore it. The general preview benefit, faster responses to any previewed digit than to a new one, persisted at every duration. Object features therefore survive motion at saccadic speed, but their link to a particular object does not.

neuroscience↗

FGF Signaling Regulates Development of the Anterior Fontanelle

The calvarial bones of the infant skull are connected by transient fibrous joints known as sutures and fontanelles, which are essential for reshaping during birth and postnatal growth. Genetic disorders such as Apert, Pfeiffer, Crouzon, and Bent bone dysplasia linked to FGFR2 variants often exhibit multi-suture craniosynostosis and a persistently open anterior fontanelle (AF). This study leverages mouse genetics and single-cell transcriptomics to determine how Fgfr2 regulates closure of the AF closure and its transformation into the frontal suture during postnatal development. We find that cells of the AF, marked by the tendon/ligament factor SCX, are spatially restricted to ecto- or endocranial domains and undergo regionally selective differentiation into ligament, bone, and cartilage. Differentiation of SCX+ AF cells is dependent on FGFR2 signaling in cells of the osteogenic fronts which, when fueled by FGF18 from the ectocranial mesenchyme, express the secreted WNT inhibitor WIF1 to regulate WNT signaling in neighboring AF cells. Upon loss of Fgfr2, Wif1 expression is lost, and cells of the AF retain a connective tissue-like fate failing to form the posterior frontal suture. This study provides new insights into regional differences in suture development by identifying an FGF-WNT signaling circuit within the AF that links frontal bone advancement with suture joint formation.

developmental biology↗