Biology subjects

Huber, D. A.

Publications and source records attributed to Huber, D. A..

2 recordsLinked to original sources

bioRxiv2025

Basal forebrain and neural correlates of self-regulation traits in sustained attention

Self-regulation is a human trait consistently associated with success in both academic and professional settings and to better mental health. Based on previous findings, we used functional imaging data in a sustained attention task to test three hypotheses on neural substrates associated with individual differences in self-regulation. The first linked higher self-regulation and cognitive control, predicting modulation of recruitment of prefrontal substrates. The second, originating in the animal literature, suggests increased recruitment of cholinergic substrates in the basal forebrain. The third predicted higher modulation of reward-sensitive regions in the brainstem in less regulated individuals for differences in reward levels during the task. The second hypothesis was confirmed by our study, which also provided suggestive evidence for the third hypothesis. Our data suggest that one mechanism of higher self-regulation in humans may ensue from greater activity in the cholinergic system to sustain attention during a cognitively simple task.

neuroscience↗

bioRxiv2024

The fMRI global signal and its association with the signal from cranial bone

The nature of the global signal, i.e. the average signal from sequential functional imaging scans of the brain or the cortex, is not well understood, but is thought to include vascular and neural components. Using resting state data, we report on the strong association between the global signal and the average signal from the part of the volume that includes the cranial bone and subdural vessels and venous collectors, separated from each other and the subdural space by multispectral segmentation procedures. While subdural vessels carried a signal with a phase delay relative to the cortex, the association with the cortical signal was strongest in the parts of the scan corresponding to the laminae of the cranial bone, reaching 80% shared variance in some individuals. These findings suggest that in resting state data vascular components may play a prominent role in the genesis of fluctuations of the global signal. Evidence from other studies on the existence of neural sources of the global signal suggests that it may reflect the action of multiple mechanisms (including cerebrovascular reactivity and autonomic control) concurrently acting to regulate global cerebral perfusion.

neuroscience↗