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Hindges, R.

Publications and source records attributed to Hindges, R..

3 recordsLinked to original sources

Excitatory and inhibitory synapses form a tight subcellular balance along dendrites that decorrelates over development

A balance between excitation and inhibition is crucial for neurotypical brain function. Indeed, disruptions in this relationship are frequently associated with the pathophysiology of neurodevelopmental disorders. Nevertheless, how this balance is established during the dynamic period of neurodevelopment remains unexplored. Using multiple techniques, including in utero electroporation, electron microscopy and electrophysiology, we reveal a tight correlation in the distribution of excitatory and inhibitory synapses along dendrites of developing CA1 hippocampal neurons. This balance was present within short dendritic stretches (<20{micro}m), and surprisingly, was most pronounced during early development, sharply declining with maturity. The tight matching between excitation and inhibition was unexpected, as inhibitory synapses lacked an active zone when formed and exhibited compromised evoked release. We propose that inhibitory synapses form as a stabilising scaffold, to counterbalance growing excitation levels. This relationship diminishes over time, suggesting a critical role for a subcellular balance in early neuronal function and circuit formation.

neuroscience↗

Alternative splicing controls teneurin-3 compact dimer formation for neuronalrecognition

Neuronal network formation is facilitated by recognition between synaptic cell adhesion molecules (CAMs) at the cell surface. Alternative splicing of CAMs provides additional specificity in forming neuronal connections. For the teneurin family of CAMs, alternative splicing of the EGF-repeats and NHL domain controls protein-protein interactions at the synapse. Here we present a 3.2 [A] cryo-EM structure of the compact dimeric ectodomain of teneurin-3 harbouring both splice inserts. This dimer is stabilised by an EGF8-ABD contact between subunits. Cryo-EM reconstructions of all four splice variants, together with SAXS and negative stain EM, reveal compacted dimers for each, with variant-specific dimeric arrangements. This results in specific trans-cellular interactions, as tested in cell clustering and stripe assays. The compact conformations provide a structural basis for teneurin homo- and heterophilic interactions. Altogether, our findings demonstrate how alternative splicing results in rearrangements of the dimeric subunits, influencing neuronal recognition and circuit wiring.

biochemistry↗

A locomotion-based assay to measure prepulse inhibition in zebrafish larvae

Sensory gating, assessed using a prepulse inhibition assay (PPI), is a promising endophenotype of neuropsychiatric disorders that can be measured in larval zebrafish models. However, current PPI assays require high-speed cameras to capture rapid c-bend startle behaviours. In this study, we designed and employed a PPI paradigm that uses locomotion as read-out of startle responses. PPI percentage was measured at a maximum of 86% and this was reduced to 42% upon administration of an NMDA receptor antagonist, MK-801. This work provides the foundation for simpler and more accessible PPI assays using larval zebrafish to model key endophenotypes of neurodevelopmental disorders.

animal behavior and cognition↗