Biology subjects

Hernandez-Walias, F. J.

Publications and source records attributed to Hernandez-Walias, F. J..

2 recordsLinked to original sources

bioRxiv2025

Bioinformatic analysis of the variability of Tax1 and Tax2 proteins of the human T-cell lymphotropic virus (HTLV)

MotivationThe pathological differentiation in humans between HTLV-1 and HTLV-2 viruses is due, among other parameters, to the variability in a viral protein, Tax (Tax1 and Tax2 respectively), with the second virus being a candidate to interfere with HIV-1 infection, which has allowed us to assess the importance of further investigating Tax. ResultsBoth the degree of conservation and the genomic and protein variability between Tax1 and Tax2 have been expressed in this work through bioinformatics tools. The knowledge about Tax2 related to the interfering capacity on HIV-1 compared to the absence of such a function in Tax1 is corroborated with our analyses, highlighting certain variations between both sequences that could explain the functional differences in pathogenicity that we show in this work. Contactroberto117343@gmail.com; hwfcojavier32@gmail.com; hwfcojavier32@hotmail.com

bioinformatics↗

bioRxiv2025

Bioinformatics Study of Genetic Variability in Obelisks

MotivationThe importance of in silico genetic variability analyses of new biological entities, such as obelisks, lies in their potential to serve as a starting point for experimental studies. The study of obelisks could open new horizons in the field of biological sciences. ResultsSeveral findings have been determined, including high conservation among the sequences within each cluster, despite the presence of significant nucleotide mutations; high variability among the Oblin-1 proteins found in the consensus sequences of each cluster, despite all sharing a known conserved region; structural consistency in the 3D model of the Oblin-2 consensus with previous studies; a series of nucleotide and protein- level consensus sequences for each cluster, where nucleotide-level patterns show color- coded conservation percentages that could be used in further research, such as primer or probe design, and protein-level sequences are presented in FASTA format for Oblin- 1, Oblin-2, and unknown Open Reading Frames (ORFs).

bioinformatics↗