Biology subjects

Hennessy, S.

Publications and source records attributed to Hennessy, S..

3 recordsLinked to original sources

bioRxiv2026

Beyond rumination: an ecological momentary assessment of daily thinking patterns in maladaptive daydreaming

Maladaptive daydreaming is a form of maladaptive repetitive thought characterized by excessive, dysfunctional fantasy engagement, with notable links to psychological distress and poor well-being. Although symptoms can be reliably measured along a continuum, it remains unclear how they manifest in the phenomenological characteristics of everyday thinking, as well as which thought characteristics are unique to maladaptive daydreaming versus shared with trait rumination, a transdiagnostic manifestation of maladaptive repetitive thinking that frequently co-occurs with maladaptive daydreaming. To advance these questions, we conducted a pre-registered study using ecological momentary assessment to track the everyday thoughts of 446 young adults (aged 18 to 34) spanning a range of maladaptive daydreaming symptom severity as assessed with the 16-item Maladaptive Daydreaming Scale. Higher maladaptive daydreaming scores were associated with several poor mental health indicators, including higher trait rumination. Positive associations between maladaptive daydreaming scores and both negatively-valenced and task-unrelated thinking emerged, yet these relationships were accounted for by variance shared with rumination. Beyond rumination, higher maladaptive daydreaming scores were uniquely associated with worse mood, as well as greater internally-oriented attention, more socially-oriented thought, and greater overall thought persistence. Maladaptive daydreaming also uniquely moderated the relationship between internal orientation and social orientation, such that the positive association between internal and social thought content became stronger at higher levels of maladaptive daydreaming. Overall, these findings provide novel evidence that maladaptive daydreaming levels are linked to unique socioemotional features and restricted dynamics, beyond its overlap with general ruminative distress in everyday life. These insights suggest that clinical interventions should target immersive fantasy engagement alongside transdiagnostic maladaptive repetitive thinking.

neuroscience↗

bioRxiv2024

Fluorescent identification of axons, dendrites and soma of neuronal retinal ganglion cells with a genetic marker as a tool for facilitating the study of neurodegeneration

This study characterizes a fluorescent Slc17a6-tdTomato neuronal reporter mouse line offering strong labeling in axons throughout the optic nerve, dendrites and soma in 99% of retinal ganglion cells (RGCs). The model facilitates neuronal assessment ex vivo with wholemounts quantified to show neurodegeneration following optic nerve crush or elevated IOP as related to glaucoma, in vitro with robust Ca2+ responses to P2X7 receptor stimulation in neuronal cultures, and in vivo using a confocal scanning laser ophthalmoscope (cSLO). While the tdTomato signal showed strong overlap with RGC markers, BRN3A and RBPMS, there was no cross-labeling of displaced amacrine cells in the ganglion cell layer. Controls indicated no impact of Slc17a6-tdTomato expression on light-dependent neuronal function, as determined with a microelectrode array (MEA), or on structure, as measured with optical coherence tomography (OCT). In summary, this novel neuronal reporter mouse model offers an effective means to increase the efficiency for real-time, specific visualization of retinal ganglion cells. It holds substantial promise for enhancing our understanding of RGC pathology in glaucoma and other diseases of the optic nerve, and could facilitate the screening of targeted therapeutic interventions for neurodegeneration. O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=140 SRC="FIGDIR/small/599589v1_ufig1.gif" ALT="Figure 1"> View larger version (40K): org.highwire.dtl.DTLVardef@13db8dforg.highwire.dtl.DTLVardef@1345f10org.highwire.dtl.DTLVardef@14d34e1org.highwire.dtl.DTLVardef@1cacb87_HPS_FORMAT_FIGEXP M_FIG Graphical abstract. Fluorescent identification of axons, dendrites and soma of neuronal retinal ganglion cells with a genetic marker as a tool for facilitating the study of neurodegeneration. Puttipong Sripinun, Wennan Lu, Sergei Nikonov, Suhani Patel, Sarah Hennessy, Claire H. Mitchell*. This study delves into a new mouse model, featuring a fluorescent Slc17a6-tdTomato neuronal reporter. This model effectively labels axons in the optic nerve, as well as dendrites and soma in 99% of retinal ganglion cells (RGCs). This allows for both in vitro and in vivo assessment of neurodegeneration, offering a practical tool for real-time, precise visualization of RGCs, with potential applications in various fields of neuroscience and neurology. Created by Biorender.com. C_FIG

neuroscience↗

bioRxiv2019

The role of lipoprotein subfractions in coronary artery disease: A Mendelian randomization study

Recent genetic data can offer important insights into the roles of lipoprotein subfractions and particle sizes in preventing coronary artery disease (CAD), as previous observational studies have often reported conflicting results. In this study, we first used the LD score regression to estimate the genetic correlation of 77 subfraction traits with traditional lipid profile and identified 27 traits that may involve distinct genetic mechanisms. We then used Mendelian randomization (MR) to estimate the causal effect of these traits on the risk of CAD. In univariable MR, the concentration and content of medium high-density lipoprotein (HDL) particles showed a protective effect against coronary artery disease. The effect was not attenuated in multivariable MR that adjusted for traditional lipid profile. The multivariable MR analyses also found that small HDL particles and smaller mean HDL particle diameter may have a protective effect. We identified four genetic markers for HDL particle size and CAD.

genetics↗