Biology subjects

HOU, J.

Publications and source records attributed to HOU, J..

2 recordsLinked to original sources

bioRxiv2024

Understanding the development of neural abnormalities in adolescents with mental health problems: a longitudinal study

Many mental health problems are neurodevelopmental in nature and have an onset during childhood. Mental health disorders are associated with neural abnormalities, but it is unclear when those emerge and how this relates to the development of different mental health problems. We used data from the largest longitudinal neurodevelopmental study to identify the structural and functional brain changes that co-occur with the onset of six mental health problems. The results showed premorbid brain-wide abnormalities that were comparable between internalizing and different from externalizing problems, and differential neurodevelopmental trajectories for specific brain regions in 11- to 12-year-old adolescents who developed ADHD, conduct, depressive and oppositional defiant problems. These results reveal that the onset of different mental health problems co-occur with common as well as problem-specific brain abnormalities.

neuroscience↗

bioRxiv2023

Pan-transcriptome reveals a large accessory genome contribution to gene expression variation in yeast

Gene expression is an essential step in the translation of genotypes into phenotypes. However, little is known about the transcriptome architecture and the underlying genetic effects at a species-level. Here, we generated and analyzed the pan-transcriptome of [~]1,000 yeast natural isolates across 4,977 core and 1,468 accessory genes. We found that the accessory genome is an underappreciated driver of the transcriptome divergence. Global gene expression patterns combined with population structure show that the heritable expression variation mainly lies within subpopulation-specific signatures, for which the accessory genes are overrepresented. Genome-wide association analyses consistently highlight that the accessory genes are associated with proportionally more variants with larger effect sizes, illustrating the critical role of the accessory genome on the transcriptional landscape within and between populations.

genomics↗