Biology subjects

Gomot, M.

Publications and source records attributed to Gomot, M..

3 recordsLinked to original sources

bioRxiv2026

Medical diagnostic radiation promotes murine Apc/Kras-driven colon carcinogenesis

Computed tomography (CT) is one of the most widely used diagnostic imaging modalities worldwide, yet the biological risks associated with such exposures remain incompletely understood. Here, we investigated the effects of clinically relevant low (25 mGy) and moderate (250 mGy) dose radiation exposures on colon carcinogenesis using in vivo KPC:APC transgenic mice and an ex vivo organoid system carrying inducible Apc and Kras driver mutations. While medical diagnostic radiation did not initiate carcinogenesis in wild-type and did not alter carcinogenesis in Apc-mutant tissues, it significantly promoted the progression of precancerous lesions in the presence of both mutations, especially when exposure occurred during early tumor initiation. Organoids derived from mice harboring both Apc and Kras mutations mirrored this susceptibility, exhibiting radiation-induced enlargement and activation of transcriptomic and proteomic programs associated with colorectal cancer, including cell-cycle dysregulation and mTORC1 pathway activation. These findings show that radiation doses within the range delivered by routine abdominal CT imaging can potentiate the carcinogenic processes in genetically predisposed cells, underscoring the need to consider individual susceptibility when evaluating the benefit-risk balance of medical diagnostic exposures.

Cancer Biology↗

bioRxiv2020

Pre-attentive processing of neutral and emotional sounds in congenital amusia

Congenital amusia is a life-long deficit of musical processing. This deficit can extend to the processing of language and in particular, emotional prosody. In a previous behavioral study, we revealed that while amusic individuals had difficulties in explicitly recognizing emotions for short vowels, they rated the emotional intensity of these same vowels as did their matched control participants. This finding led to the hypothesis that congenital amusics might be impaired for explicit emotional prosody recognition, but not for its implicit processing. With the aim to investigate amusics automatic processing of prosody, the present study measured electroencephalography (EEG) when participants listened passively to vowels presented within an oddball paradigm. Emotionally neutral vowel served as the standard and either emotional (anger and sadness) or neutral vowels as deviants. Evoked potentials were compared between participants with congenital amusia and control participants matched in age, education, and musical training. The MMN was rather preserved for all deviants in amusia, whereas an earlier negative component was found decreased in amplitude in amusics compared to controls for the neutral and sadness deviants. For the most salient deviant (anger), the P3a was decreased in amplitude for amusics compared to controls. These results showed some preserved automatic detection of emotional deviance in amusia despite an early deficit to process subtle acoustic changes. In addition, the automatic attentional shift in response to salient deviants at later processing stages was reduced in amusics in comparison to the controls. In the three ERPs related to the deviance, between-group differences were larger over bilateral prefrontal areas, previously shown to display functional impairments in congenital amusia. Our present study thus provides further understanding of the dichotomy between implicit and explicit processing in congenital amusia, in particular for vocal stimuli with emotional content.

neuroscience↗

bioRxiv2018

Emotional prosody in congenital amusia: impaired and spared processes

Congenital amusia is a lifelong deficit of music processing, in particular of pitch processing. Most research investigating this neurodevelopmental disorder has focused on music perception, but pitch also has a critical role for intentional and emotional prosody in speech. Two previous studies investigating amusics emotional prosody recognition have shown either some deficit or no deficit (compared to controls). However, these previous studies have used only long sentence stimuli, which allow for limited control over acoustic content. Here, we tested amusic individuals for emotional prosody perception in sentences and vowels. For each type of material, participants performed an emotion categorization task, followed by intensity ratings of the recognized emotion. Compared to controls, amusic individuals had similar recognition of emotion in sentences, but poorer performance in vowels, especially when distinguishing sad and neutral stimuli. These lower performances in amusics were linked with difficulties in processing pitch and spectro-temporal parameters of the vowel stimuli. For emotion intensity, neither sentence nor vowel ratings differed between participant groups, suggesting preserved implicit processing of emotional prosody in amusia. These findings can be integrated into previous data showing preserved implicit processing of pitch and emotion in amusia alongside deficits in explicit recognition tasks. They are thus further supporting the hypothesis of impaired conscious analysis of pitch and timbre in this neurodevelopmental disorder.\n\nHighlightsO_LIAmusics showed preserved emotional prosody recognition in sentences\nC_LIO_LIAmusics showed a deficit for emotional prosody recognition in short voice samples\nC_LIO_LIPreserved intensity ratings of emotions in amusia suggest spared implicit processes\nC_LI

neuroscience↗