Biology subjects

Goiaeva, D. E.

Publications and source records attributed to Goiaeva, D. E..

4 recordsLinked to original sources

bioRxiv2025

Vowel-like patterns modulate auditory P100m response but not its association with language abilities in children with ASD

BackgroundThe P100/P100m component of auditory event-related potentials/fields is considered a potential biomarker of atypical arousal and language abnormalities in children with ASD. When elicited by complex speech-like sounds with regular temporal or frequency structure, P100/P100m may be influenced by sustained negativity (SN), which can reduce its amplitude due to opposing current polarity. MethodsUsing MEG, we investigated how acoustic regularities affect P100m latency and amplitude differences between TD children and those with ASD. MEG was recorded in 35 ASD and 39 TD boys (7-12 years) in response to control sounds (non-periodic, non-vowels) and stimuli with temporal regularity (periodic non-vowels), frequency regularity (non-periodic vowels), or both (periodic vowels). P100m was estimated using distributed source localization. ResultsIn both groups, P100m amplitude and latency decreased in response to acoustic regularities, accompanied by a proportional increase in SN. No group differences were observed in P100m latency, amplitude, or their modulation by stimulus characteristics. In ASD, P100m latency variability was increased, and higher P100m amplitudes in the left auditory cortex were negatively associated with cumulative language and intellectual abilities. ConclusionsIn children, changes in P100m in response to acoustic regularities are most parsimoniously explained by an enhancement of SN with opposite polarity. No consistent relationship was found between P100m parameters or their modulation by acoustic regularities and ASD diagnosis. However, variations in cortical maturation and/or habituation processes, which affect the left-hemispheric P100m, may be relevant to cognitive and language functioning in children with ASD.

neuroscience↗

bioRxiv2024

Attenuated processing of vowels in the left hemisphere predicts speech-in-noise perception deficit in children with autism

BackgroundDifficulties with speech-in-noise perception in autism spectrum disorders (ASD) may be associated with impaired analysis of speech sounds, such as vowels, which represent the fundamental phoneme constituents of human speech. Vowels elicit early (< 100 ms) sustained processing negativity (SPN) in the auditory cortex that reflects the detection of an acoustic pattern based on the presence of formant structure and/or periodic envelope information (f0) and its transformation into an auditory "object". MethodsWe used magnetoencephalography (MEG) and individual brain models to investigate whether SPN is altered in children with ASD and whether this deficit is associated with impairment in their ability to perceive speech in the background of noise. MEG was recorded while boys with ASD and typically developing boys passively listened to sounds that differed in the presence/absence of f0 periodicity and formant structure. Word-in-noise perception was assessed in the separate psychoacoustic experiment using stationary and amplitude modulated noise with varying signal-to-noise ratio. ResultsSPN was present in both groups with similarly early onset. In children with ASD, SPN associated with processing formant structure was reduced predominantly in the cortical areas lateral to and medial to the primary auditory cortex, starting at [~] 150 - 200 ms after the stimulus onset. In the left hemisphere, this deficit correlated with impaired ability of children with ASD to recognize words in amplitude-modulated noise, but not in stationary noise ConclusionsThese results suggest that perceptual grouping of vowel formants into phonemes is impaired in children with ASD and that, in the left hemisphere, this deficit contributes to their difficulties with speech perception in fluctuating background noise.

neuroscience↗

bioRxiv2020

Left hemispheric deficit in the sustained neuromagnetic response to periodic click trains in children with ASD.

Deficits in perception and production of vocal pitch are often observed in people with autism spectrum disorders (ASD), but the neural basis of these abnormalities is unknown. In magnetoencephalogram (MEG), spectrally complex periodic sounds trigger two continuous neural responses - the Auditory Steady State Response (ASSR) and the Sustained Field (SF). It has been shown that the SF in neuro-typical individuals is associated with low-level analysis of pitch in the pitch processing center of the Heschls gyrus. Therefore, this auditory response may reflect vocal pitch processing abnormalities in ASD. The SF, however, has never been studied in people with these disorders. We used MEG and individual brain models to investigate the ASSR and SF evoked by monaural 40 Hz click trains in 7-13-year-old boys with ASD (N=35) and neuro-typical (NT) boys (N=35). In agreement with the previous research in adults, the cortical sources of the SF in children were located in the left and the right Heschls gyri, anterolateral to those of the ASSR. In both groups, the SF and ASSR dominated in the right hemisphere and were higher contralaterally to the stimulated ear. The ASSR increased with age in both NT and ASD children and did not differ between the groups. The SF was moderately decreased in both hemispheres and was markedly delayed and displaced in the left hemisphere in boys with ASD. The SF delay in participants with ASD was present irrespective of their intelligence level and severity of autism symptoms. We suggest that the selective left-hemispheric SF abnormalities in children with ASD reflect a low-level deficiency in pitch processing that may contribute to their difficulties with perception and production of linguistic prosody.

neuroscience↗

bioRxiv2017

Modulation of visual gamma oscillation by excitatory drive and the excitation/inhibition balance in the visual cortex

Gamma-band oscillations arise from the interplay between neural excitation (E) and inhibition (I) and may provide a non-invasive window into the state of cortical circuitry. A bell-shaped modulation of gamma response power by increasing the intensity of sensory input was observed in animals and is thought to reflect neural gain control. Here we sought to find a similar input-output relationship in humans with MEG via modulating the intensity of a visual stimulation by changing the velocity/temporal-frequency of visual motion.\n\nIn the first experiment, adult participants observed static and moving gratings. The frequency of the MEG gamma response monotonically increased with motion velocity whereas power followed a bell-shape. In the second experiment, on a large group of children and adults, we found that despite drastic developmental changes in frequency and power of gamma oscillations, the relative suppression at high motion velocities was scaled to the same range of values across the life-span.\n\nIn light of animal and modeling studies, the modulation of gamma power and frequency at high stimulation intensities characterizes the capacity of inhibitory neurons to counterbalance increasing excitation in visual networks. Gamma suppression may thus provide a non-invasive measure of inhibitory-based gain control in the healthy and diseased brain.

neuroscience↗