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Fischi-Gomez, E.

Publications and source records attributed to Fischi-Gomez, E..

6 recordsLinked to original sources

OCTOPUS: A versatile open-source tool creating realistic numericalbrain cells

Brain cell morphology plays a crucial role in function and pathology. Biophysical models of diffusion MRI (dMRI) quantify cell morphology in vivo, enabling the design of novel biomarkers. These models represent cells by simplified geometries, such as spheres and randomly oriented cylinders, for which analytical signal expressions exist. However, dMRI signals are sensitive to morphological features, such as branching, tapering, undulation, beading, and protrusions, unaccounted for in most models, as they often render analytical solutions impossible. Simulations of the dMRI signal in synthetically generated cells offer a powerful tool to explore how microstructural morphology impacts the dMRI signal. Nevertheless, no tool to generate digital replicas of brain cells is available openly. To address this gap, we introduce the OCTOPUS toolbox, which generates cells featuring all geometrical features described above. OCTOPUS, provided via the Python interface OCTOpool, enables accessible, efficient creation of cells with complex geometries. We recreated histologically reconstructed neuronal and glial cells, including pyramidal, GABAergic and glutamatergic neurons, and astro- and microglia. To illustrate the plausibility of OCTOPUS-generated cells, we reproduced established properties of dMRI signals from brain tissue, such as the signatures of short-range disorder, branching and protrusions, and a high-b-value power law. By comparing the geometries and dMRI signals of generated and original cells, we found different growth strategies adequate for more isotropic and more anisotropic cells. We anticipate that realistic cell substrates created by OCTOPUS will help validate biophysical models, design dMRI sequences sensitive to fine-grained cell morphology beyond analytical models, and generate realistic numerical substrates of brain tissue.

neuroscience↗

Regional BOLD variability reflects microstructural maturation and neuronal ensheathment in the preterm infant cortex

BOLD variability reflects meaningful brain activity, yet its structural and biological correlates during early development remain unknown. We aimed to investigate how BOLD variability evolves in very preterm (VPT) infants, its relationship with cortical microstructure and gene expression, and how it differs from full-term (FT) newborns at term-equivalent age (TEA). Using resting-state fMRI and multi-shell diffusion imaging, acquired in 54 VPT (longitudinally at 33-weeks GA and at TEA) and 24 FT newborns, we evaluated regional differences in cortical BOLD variability and microstructural maturation, and compared to patterns of gene expression in the fetal cortex, using the BrainSpan dataset. BOLD variability increased in primary sensory-sensorimotor and proto-DMN regions, accompanied by decreased cortical diffusivity. Gene expression analysis revealed concurrent upregulation of genes mediating gliogenesis and neuronal ensheathment. Compared to FT newborns, VPT at TEA showed decreased BOLD variability and increased cortical diffusivity. BOLD variability reflects cortical microstructure, mediated by upregulation of gliogenesis and neuronal ensheathment. Interruption of these processes by preterm birth identifies putative mechanisms of preterm brain injury.

neuroscience↗

Defacing biases visual quality assessments of structural MRI

A critical step before data-sharing of human neuroimaging is removing facial features to protect individuals privacy. However, not only does this process redact identifiable information about individuals, but it also removes non-identifiable information. This introduces undesired variability into downstream analysis and interpretation. This registered report investigated the degree to which the so-called defacing altered the quality assessment of T1-weighted images of the human brain from the openly available "IXI dataset". The effect of defacing on manual quality assessment was investigated on a single-site subset of the dataset (N=185). By comparing two linear mixed-effects models, we determined that four trained human raters perception of quality was significantly influenced by defacing by modeling their ratings on the same set of images in two conditions: "nondefaced" (i.e., preserving facial features) and "defaced". In addition, we investigated these biases on automated quality assessments by applying repeated-measures, multivariate ANOVA (rm-MANOVA) on the image quality metrics extracted with MRIQC on the full IXI dataset (N=581; three acquisition sites). This study found that defacing altered the quality assessments by humans and showed that MRIQCs quality metrics were mostly insensitive to defacing.

bioinformatics↗

Do you see what I see? Diffusion imaging protocol heterogeneity biases ischemic core volume, location, and clinical associations in acute stroke

PurposeDiffusion-weighted magnetic resonance imaging (DWI) is essential for diagnosing ischemic stroke and identifying targets for emergency revascularization. Apparent diffusion coefficient (ADC) maps derived from DWI are commonly used to locate the infarct core, but they are not strictly quantitative and can vary across platforms and sites due to technical factors. This retrospective study was conducted to examine how differences in ADC map generation, resulting from varied protocols across platforms and sites, affect the determination of infarct core size, location, and related clinical outcomes in acute stroke. MethodsIn this retrospective study, 726 acute anterior circulation stroke patients admitted to the Lausanne University Hospital between May 2018 and January 2021 were selected. DWI data were used to generate ADC maps as they would appear from different protocols: two simulated with low and medium angular resolution (4 and 12 diffusion gradient directions) and one with high angular resolution (20 directions). Using a DEFUSE like criteria and image post-processing, ischemic cores were localized; core volume, location, and associations to National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) scores were compared between the two imaging sequences. ResultsSignificant differences were observed in the ADC distribution within white matter, particularly in the kurtosis and skewness, with the segmented infarct core volume being higher in protocols with reduced angular resolution compared to the 20-directions data (7.63 ml vs. 3.78 ml). The volumetric differences persisted after correcting for age, sex, and type of intervention. Infarcted voxels locations varied significantly between the two protocols. This variability affected associations between infarct core volume and clinical scores, with lower associations observed for 4-directions data compared to 20-directions data for NIHSS at admission and after 24 hours, and mRS after 3 months, further confirmed by multivariate regression. ConclusionsImaging protocol heterogeneity leads to significant changes in the ADC distribution, ischemic core location, size, and association with clinical scores. Work is needed in standardizing imaging protocols to improve the reliability of ADC as an imaging biomarker in stroke management.protocols to improve the reliability of ADC as an imaging biomarker in stroke management. Key ResultsO_LIOrientation changes in diffusion imaging significantly impact ADC distribution and threshold-based infarct core volume determination, affecting multi-centric studies. C_LIO_LILower number of directions in DWI acquisitions weakens associations between infarct volume measurements and clinical scores. C_LIO_LIFindings emphasize the impact of DWI acquisition protocol heterogeneity and image processing on acute stroke workups. C_LI

neuroscience↗

Insights from the IronTract challenge: optimal methods for mapping brain pathways from multi-shell diffusion MRI

Limitations in the accuracy of brain pathways reconstructed by diffusion MRI (dMRI) tractography have received considerable attention. While the technical advances spearheaded by the Human Connectome Project (HCP) led to significant improvements in dMRI data quality, it remains unclear how these data should be analyzed to maximize tractography accuracy. Over a period of two years, we have engaged the dMRI community in the IronTract Challenge, which aims to answer this question by leveraging a unique dataset. Macaque brains that have received both tracer injections and ex vivo dMRI at high spatial and angular resolution allow a comprehensive, quantitative assessment of tractography accuracy on state-of-the-art dMRI acquisition schemes. We find that, when analysis methods are carefully optimized, the HCP scheme can achieve similar accuracy as a more time-consuming, Cartesian-grid scheme. Importantly, we show that simple pre- and post-processing strategies can improve the accuracy and robustness of many tractography methods. Finally, we find that fiber configurations that go beyond crossing (e.g., fanning, branching) are the most challenging for tractography. The IronTract Challenge remains open and we hope that it can serve as a valuable validation tool for both users and developers of dMRI analysis methods.

neuroscience↗

Tractography dissection variability: what happens when 42 groups dissect 14 white matter bundles on the same dataset?

White matter bundle segmentation using diffusion MRI fiber tractography has become the method of choice to identify white matter fiber pathways in vivo in human brains. However, like other analyses of complex data, there is considerable variability in segmentation protocols and techniques. This can result in different reconstructions of the same intended white matter pathways, which directly affects tractography results, quantification, and interpretation. In this study, we aim to evaluate and quantify the variability that arises from different protocols for bundle segmentation. Through an open call to users of fiber tractography, including anatomists, clinicians, and algorithm developers, 42 independent teams were given processed sets of human whole-brain streamlines and asked to segment 14 white matter fascicles on six subjects. In total, we received 57 different bundle segmentation protocols, which enabled detailed volume-based and streamline-based analyses of agreement and disagreement among protocols for each fiber pathway. Results show that even when given the exact same sets of underlying streamlines, the variability across protocols for bundle segmentation is greater than all other sources of variability in the virtual dissection process, including variability within protocols and variability across subjects. In order to foster the use of tractography bundle dissection in routine clinical settings, and as a fundamental analytical tool, future endeavors must aim to resolve and reduce this heterogeneity. Although external validation is needed to verify the anatomical accuracy of bundle dissections, reducing heterogeneity is a step towards reproducible research and may be achieved through the use of standard nomenclature and definitions of white matter bundles and well-chosen constraints and decisions in the dissection process.

neuroscience↗