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Fernandez-Garcia, M.

Publications and source records attributed to Fernandez-Garcia, M..

2 recordsLinked to original sources

Bone collagen hydrogen isotopes as tracers of local palaeoclimate: The Aurignacian from Isturitz cave (France) as a case study

Hydrogen stable isotopes ({delta}2H) preserved in bone collagen have been proposed as a promising proxy for palaeoclimatic reconstruction, though empirical applications remain limited. To evaluate the reliability and scope of this approach, we performed a multiisotopic analysis ({delta}13C, {delta}15N, {delta}34S, and {delta}2H) on 50 herbivore bone samples collected from three archaeostratigraphic layers spanning the Aurignacian sequence of Isturitz Cave (France). This archaeological well-preserved, dated and studied site provides a robust framework for testing isotopic proxies across temporal and taxonomic gradients. Our results reveal a progressive {delta}2H depletion over [~]3000-year interval, consistent with predicted increasing aridity. We also identified species-specific {delta}2H differences, underscoring the need for taxonomic resolution in future applications and in general palaeoclimatic interpretations. While these samples reflect faunal remains accumulated through human activity--introducing potential ecological and sampling biases--they nonetheless provide valuable records of past local conditions. Overall, our findings support the potential of bone collagen {delta}2H as a sensitive indicator of past hydrological conditions and a complementary tool for reconstructing both climatic trends and humanenvironment dynamics.

ecology↗

Dynamic stress- and inflammatory-based regulation of psychiatric risk loci in human neurons

The immune environment influences neurodevelopment and subsequent clinical trajectories for psychiatric outcomes in childhood and adolescence. Yet it remains unclear if the impact of maternal and fetal immune activation varies with distinct polygenic risk profiles. Therefore, here we catalogue genotype and environment (GxE) interactions, contrasting allele-specific regulatory activity between inflammatory cues. We report a cue-specific neuronal massively parallel reporter assay (MPRA) of 152 loci from genome-wide association study (GWAS) linked to ten brain traits/disorders, empirically dissecting the impact of interleukin-6 (IL-6) and interferon-alpha (IFN) on transcriptional activity. In human induced pluripotent stem cell (hiPSC)-derived glutamatergic neurons, 1,156 active candidate regulatory risk sequences (MPRA-active CRSs) are resolved, including 267 with variant-specific effects (MPRA-emVars) and 61 with variant-by-cytokine interaction effects (interaction MPRA-emVars). Broadly, neuronal immune-mediated regulatory activity is associated with differences in transcription factor binding and chromatin accessibility, the gene targets of which show pleiotropic enrichments for brain, metabolic, and immune disorders. Dynamic genetic regulation mediates neuroimmune effects, informing our understanding of the genomics of psychiatric and neurological traits, mechanisms governing pleiotropy across disorders, and how immune mechanisms mediate genetic risk.

genetics↗