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Eller, P.

Publications and source records attributed to Eller, P..

2 recordsLinked to original sources

Climatic clustering and longitudinal analysis with impacts on food, bioenergy, and pandemics

Predicted growth in world population will put unparalleled stress on the need for sustainable energy and global food production, as well as increase the likelihood of future pandemics. In this work, we identify high-resolution environmental zones in the context of a changing climate and predict longitudinal processes relevant to these challenges. We do this using exhaustive vector comparison methods that measure the climatic similarity between all locations on earth at high geospatial resolution. The results are captured as networks, in which edges between geolocations are defined if their historical climates exceed a similarity threshold. We then apply Markov clustering and our novel Correlation of Correlations method to the resulting climatic networks, which provides unprecedented agglomerative and longitudinal views of climatic relationships across the globe. The methods performed here resulted in the fastest (9.37 x 1018 operations/sec) and one of the largest (168.7 x 1021 operations) scientific computations ever performed, with more than 100 quadrillion edges considered for a single climatic network. Correlation and network analysis methods of this kind are widely applicable across computational and predictive biology domains, including systems biology, ecology, carbon cycles, biogeochemistry, and zoonosis research.

systems biology↗

TIS7 and SKMc15 Regulate Adipocyte Differentiation and Intestinal Lipid Absorption

Delta-like homolog 1 (DLK1), an inhibitor of adipogenesis, controls the cell fate of adipocyte progenitors. Here we identify two independent regulatory mechanisms, transcriptional and translational, by which TIS7 (IFRD1) and its orthologue SKMc15 (IFRD2) regulate DLK1 levels. Mice deficient in both TIS7 and SKMc15 (dKO) had severely reduced adipose tissue and were resistant to high fat diet-induced obesity. Wnt signaling, a negative regulator of adipocyte differentiation was significantly up regulated in dKO mice. Elevated levels of the Wnt/{beta}-catenin target protein Dlk-1 inhibited the expression of adipogenesis regulators PPAR{gamma} and C/EBP, and fatty acid transporter CD36. Although both, TIS7 and SKMc15, contributed to this phenotype, they utilized two different mechanisms. TIS7 acted by controlling Wnt signaling and thereby transcriptional regulation of Dlk-1. On the other hand, here we provide distinctive experimental evidence that SKMc15 acts as a general translational inhibitor significantly affecting DLK-1 protein levels. Our study provides data describing novel mechanisms of DLK1 regulation in adipocyte differentiation involving TIS7 and SKMc15. SYNOPSIS O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=184 SRC="FIGDIR/small/719922v3_ufig1.gif" ALT="Figure 1"> View larger version (47K): org.highwire.dtl.DTLVardef@77d89corg.highwire.dtl.DTLVardef@2e0ad4org.highwire.dtl.DTLVardef@c923fdorg.highwire.dtl.DTLVardef@159d117_HPS_FORMAT_FIGEXP M_FIG C_FIG This study uncovered that IFRD1 (TIS7) and its orthologue IFRD2 (SKMc15) are two essential regulators of adipogenesis. These proteins are highly similar on the sequence level, yet they regulate adipocyte differentiation using different but complementary mechanisms. Our main findings are: O_LIIFRD1 (TIS7) and IFRD2 (SKMc15) knockout mice are resistant against diet-induced obesity C_LIO_LIIFRD1 (TIS7) and IFRD2 (SKMc15) are critical for proper nutritional fat uptake and adipogenesis C_LIO_LIIFRD1 (TIS7) controls adipogenesis via Wnt/{beta}-catenin-dependent transcriptional regulation of adipocyte-specific genes C_LIO_LIIFRD2 (SKMc15) regulates adipocyte-specific genes acting as a novel general translational inhibitor C_LI

cell biology↗